
Azaserine
CAS No. 115-02-6
Azaserine ( CI-337 | O-Diazoacetyl-L-serine | P-165 )
产品货号. M29606 CAS No. 115-02-6
Azaserine 是一种从链霉菌属中分离出来的肿瘤抑制抗生素,具有谷氨酰胺酰胺转移酶抑制剂的作用。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥413 | 有现货 |
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100MG | 获取报价 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Azaserine
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Azaserine 是一种从链霉菌属中分离出来的肿瘤抑制抗生素,具有谷氨酰胺酰胺转移酶抑制剂的作用。
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产品描述Azaserine is a tumor-inhibiting antibiotic isolated from a species of Streptomyces and functions as an inhibitor of glutamine amidotransferase.(In Vitro):Azaserine inhibits the hexosamine biosynthetic pathway, which shunts excessive intracellular glucose into the biosynthesis of UDP-N-acetylglucosamine and the formation of O-linked glycoproteins . Azaserine (25 μM) inhibits the glutamine-dependent amidotransferases involved in nucleotide biosynthesis, phosphoribosylformylglycinamidine synthetase, and glucosamine-6-phosphate isomerase.
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体外实验Azaserine (100 μg/mL; 6 h) causes some specific types of morphological changes of the sensitive organisms such as the characteristic elongation of Candida albicans cells.Azaserine (0-10 μM) inhibits the growth of E. coli strains with MIC values of 12.11, 51.9, 69.2 and 69.2 μg/mL for UTH 4, UTH 7036, UTH 7048 and UTH 7049.
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体内实验Azaserine (5 mg/kg; i.p. once or twice a week for 6 months) induces tumor in rats. Animal Model:Wistar rats Dosage:5 mg/kg Administration:Intraperitoneal injection; 5 mg/kg once or twice a week for 6 month Result:After 1 year most pancreases from treated rats were diffusely abnormal and contained many hyperplastic nodules and adenomas and more than rats one-quarter showed pancreatic adenocarcinoma.
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同义词CI-337 | O-Diazoacetyl-L-serine | P-165
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通路Others
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靶点Other Targets
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number115-02-6
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分子量173.128
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分子式C5H7N3O4
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纯度>98% (HPLC)
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溶解度In Vitro:?H2O : 50 mg/mL (288.80 mM)
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SMILESN[C@@H](COC(=O)C=[N+]=[N-])C(O)=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years