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Azaserine

CAS No. 115-02-6

Azaserine ( CI-337 | O-Diazoacetyl-L-serine | P-165 )

产品货号. M29606 CAS No. 115-02-6

Azaserine 是一种从链霉菌属中分离出来的肿瘤抑制抗生素,具有谷氨酰胺酰胺转移酶抑制剂的作用。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥413 有现货
100MG 获取报价 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Azaserine
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    Azaserine 是一种从链霉菌属中分离出来的肿瘤抑制抗生素,具有谷氨酰胺酰胺转移酶抑制剂的作用。
  • 产品描述
    Azaserine is a tumor-inhibiting antibiotic isolated from a species of Streptomyces and functions as an inhibitor of glutamine amidotransferase.(In Vitro):Azaserine inhibits the hexosamine biosynthetic pathway, which shunts excessive intracellular glucose into the biosynthesis of UDP-N-acetylglucosamine and the formation of O-linked glycoproteins . Azaserine (25 μM) inhibits the glutamine-dependent amidotransferases involved in nucleotide biosynthesis, phosphoribosylformylglycinamidine synthetase, and glucosamine-6-phosphate isomerase.
  • 体外实验
    Azaserine (100 μg/mL; 6 h) causes some specific types of morphological changes of the sensitive organisms such as the characteristic elongation of Candida albicans cells.Azaserine (0-10 μM) inhibits the growth of E. coli strains with MIC values of 12.11, 51.9, 69.2 and 69.2 μg/mL for UTH 4, UTH 7036, UTH 7048 and UTH 7049.
  • 体内实验
    Azaserine (5 mg/kg; i.p. once or twice a week for 6 months) induces tumor in rats. Animal Model:Wistar rats Dosage:5 mg/kg Administration:Intraperitoneal injection; 5 mg/kg once or twice a week for 6 month Result:After 1 year most pancreases from treated rats were diffusely abnormal and contained many hyperplastic nodules and adenomas and more than rats one-quarter showed pancreatic adenocarcinoma.
  • 同义词
    CI-337 | O-Diazoacetyl-L-serine | P-165
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    ——
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    115-02-6
  • 分子量
    173.128
  • 分子式
    C5H7N3O4
  • 纯度
    >98% (HPLC)
  • 溶解度
    In Vitro:?H2O : 50 mg/mL (288.80 mM)
  • SMILES
    N[C@@H](COC(=O)C=[N+]=[N-])C(O)=O
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

产品手册
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