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Ayanin
CAS No. 572-32-7
Ayanin ( —— )
产品货号. M29095 CAS No. 572-32-7
Ayanin 具有血管舒张活性，也可能具有用于治疗过敏性哮喘的潜力。 Ayanin 抑制纯化嗜碱性粒细胞产生白细胞介素 IL-4 的 IC50 值为 2.2microM。 Ayanin 是一种非选择性磷酸二酯酶1-4 抑制剂，可用于呼吸系统疾病研究。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥5038 | 有现货 |
|
| 10MG | ￥7120 | 有现货 |
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| 25MG | ￥10368 | 有现货 |
|
| 50MG | ￥14175 | 有现货 |
|
| 100MG | ￥19197 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Ayanin
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Ayanin 具有血管舒张活性，也可能具有用于治疗过敏性哮喘的潜力。 Ayanin 抑制纯化嗜碱性粒细胞产生白细胞介素 IL-4 的 IC50 值为 2.2microM。 Ayanin 是一种非选择性磷酸二酯酶1-4 抑制剂，可用于呼吸系统疾病研究。
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产品描述Ayanin has vasorelaxant activity, it also may have the potential for use in treating allergic asthma. The IC50 value of Ayanin is 2.2microM for inhibiting interleukin IL-4 production from purified basophils. Ayanin is a non-selective phosphodiesterase1-4 inhibitor and can be used for respiratory disease researches.(In Vitro):Incubation of human leukemia cells with Ayanin diacetate induced G(2)-M phase cell cycle arrest and apoptosis which was prevented by the non-specific caspase inhibitor z-VAD-fmk and reduced by the overexpression of Bcl-x(L). Ayanin diacetate-induced cell death was found to be associated with: (i) loss of inner mitochondrial membrane potential, (ii) the release of cytochrome c, (iii) the activation of multiple caspases, (iv) cleavage of poly(ADP-ribose) polymerase and (v) the up-regulation of death receptors for TRAIL, DR4 and DR5. Moreover, the combined treatment with Ayanin diacetate and TRAIL amplified cell death, compared to single treatments.
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体外实验Ayanin inhibits interleukin (IL)-4 production from purified basophils with an IC50 value of 2.2 μM.
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体内实验——
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同义词——
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通路Apoptosis
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靶点IL Receptor
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受体IL Receptor
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研究领域——
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适应症——
化学信息
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CAS Number572-32-7
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分子量344.319
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分子式C18H16O7
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 250 mg/mL (726.07 mM)
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SMILESCOc1cc(O)c2c(c1)oc(-c1ccc(OC)c(O)c1)c(OC)c2=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
产品手册
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