Aumitin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Aumitin 是一种新型有效的自噬抑制剂，针对饥饿和雷帕霉素诱导的自噬的 IC50 分别为 124 和 244 nM。

Aumitin is a novel potent autophagy inhibitor with IC50 of 124 and 244 nM against starvation- and rapamycin- induced autophagy respectively, targets mitochondrial complex I; inhibits LC3 lipidation, and p62 degradation by starvation- as well as rapamycin-induced autophagy dose-dependently in MCF7-LC3 cells, suggesting inhibition of autophagic flux; inhibits mitochondrial respiration by targeting complex I with IC50 of 0.11 uM in HeLa cells; Aumitin is a new tool compound for interrogating autophagy and mitochondrial respiration by means of complex I inhibition.

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Aumitin

Autophagy

Autophagy

Autophagy

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946293-78-3

429.908

C24H20ClN5O

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (232.61 mM)

O=C(NC1=CC=C(NC2=NC(NC3=CC=CC=C3)=CC(C)=N2)C=C1)C4=CC=CC=C4Cl

2-chloro-N-(4-((4-methyl-6-(phenylamino)pyrimidin-2-yl)amino)phenyl)benzamide

(-20℃)

With Ice Pack

≥ 2 years