Apicidin ( OSI 2040 )

产品货号. M12833 CAS No. 183506-66-3

Apicidin (OSI 2040) is a fungal metabolite that exhibits potent, broad spectrum antiprotozoal activity in vitro.

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
100MG	获取报价	有现货
200MG	获取报价	有现货
500MG	获取报价	有现货
1G	获取报价	有现货

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生物学信息

产品名称

Apicidin
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Apicidin (OSI 2040) is a fungal metabolite that exhibits potent, broad spectrum antiprotozoal activity in vitro.
产品描述

Apicidin (OSI 2040) is a fungal metabolite that exhibits potent, broad spectrum antiprotozoal activity in vitro, potently inhibits HDAC with IC50 of 0.7 nM in an enzyme activity assay; induces morphological changes, cell cycle arrest at G1 phase, and accumulation of hyperacetylated histone H4 in Hela cells, changes the expression of p21WAF1/Cip1 and gelsolin; upregulates Foxa2 expression via hyperacetylation of H3 and a decrease in H3K27 trimethylation on the promoter regions.
同义词

OSI 2040
通路

Cell Cycle/DNA Damage
靶点

HDAC
受体

HDAC
研究领域

Cancer
适应症

——

化学信息

CAS Number

183506-66-3
分子量

623.78
分子式

C34H49N5O6
纯度

>98% (HPLC)
溶解度

——
SMILES

O=C(N[C@@H](CCCCCC(CC)=O)C(N[C@@H](CC(N1OC)=CC2=C1C=CC=C2)C(N[C@H]3[C@H](C)CC)=O)=O)[C@](CCCC4)([H])N4C3=O
化学全称

cyclo[(2S)-2-amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl]

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1. Darkin-Rattray SJ, et al. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13143-7.
2. Han JW, et al. Cancer Res. 2000 Nov 1;60(21):6068-74.
3. Bang SY, et al. Stem Cells Dev. 2015 Feb 15;24(4):520-33.

计算器

浓度计算器

摩尔计算器

分子量计算器

产品手册