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Apicidin
CAS No. 183506-66-3
Apicidin ( OSI 2040 )
产品货号. M12833 CAS No. 183506-66-3
Apicidin (OSI 2040) is a fungal metabolite that exhibits potent, broad spectrum antiprotozoal activity in vitro.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Apicidin
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Apicidin (OSI 2040) is a fungal metabolite that exhibits potent, broad spectrum antiprotozoal activity in vitro.
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产品描述Apicidin (OSI 2040) is a fungal metabolite that exhibits potent, broad spectrum antiprotozoal activity in vitro, potently inhibits HDAC with IC50 of 0.7 nM in an enzyme activity assay; induces morphological changes, cell cycle arrest at G1 phase, and accumulation of hyperacetylated histone H4 in Hela cells, changes the expression of p21WAF1/Cip1 and gelsolin; upregulates Foxa2 expression via hyperacetylation of H3 and a decrease in H3K27 trimethylation on the promoter regions.
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同义词OSI 2040
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通路Cell Cycle/DNA Damage
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靶点HDAC
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受体HDAC
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研究领域Cancer
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适应症——
化学信息
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CAS Number183506-66-3
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分子量623.78
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分子式C34H49N5O6
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纯度>98% (HPLC)
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溶解度——
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SMILESO=C(N[C@@H](CCCCCC(CC)=O)C(N[C@@H](CC(N1OC)=CC2=C1C=CC=C2)C(N[C@H]3[C@H](C)CC)=O)=O)[C@](CCCC4)([H])N4C3=O
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化学全称cyclo[(2S)-2-amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl]
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Darkin-Rattray SJ, et al. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13143-7.
2. Han JW, et al. Cancer Res. 2000 Nov 1;60(21):6068-74.
3. Bang SY, et al. Stem Cells Dev. 2015 Feb 15;24(4):520-33.
2. Han JW, et al. Cancer Res. 2000 Nov 1;60(21):6068-74.
3. Bang SY, et al. Stem Cells Dev. 2015 Feb 15;24(4):520-33.
