Antroquinonol

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Antroquinonol ((+)-Antroquinonol) 是一种来源于 Antrodia camphorata 的泛醌衍生物，具有保肝、抗炎和抗癌作用。Antroquinonol 可用于结肠癌的研究。Antroquinonol 通过增强 Nrf2 信号通路降低氧化应激，抑制局灶节段性肾小球硬化小鼠的炎症和硬化。

Antroquinonol ((+)-Antroquinonol), a ubiquinone derivative from the mushroom Antrodia camphorata, has hepatoprotective, anti-inflammatory, and anti-cancer effects. Antroquinonol can be used for the research of colon cancer. Antroquinonol reduces oxidative stress by enhancing the Nrf2 signaling pathway and inhibits inflammation and sclerosis in focal segmental glomerulosclerosis mice.

Antroquinonol is a ubiquinone derivative from A.camphorata. Antroquinonol inhibits cell growth and suppresses the migratory/invasive ability of human colon cancer cells. Antroquinonol at high concentrations (40-80 μM) exhibits growth inhibitory activities in the three colon cancer cell lines, whereas low concentrations of Antroquinonol (2.5-20 μM) shows modest growth inhibition. Antroquinonol possesses the ability to inhibit breast cancer migration/invasion by inhibiting the EMT and MMP-9 gene expression.Antroquinonol has inducible nitric oxide synthase (iNOS) inhibitory activity in lipopolysaccharide (LPS)-activated macrophages, anti-inflammatory activity in macrophage cell cultures by reducing the production of tumor necrosis factor-α and interleukin (IL)-1β, and anti-cancer activity against hepatoma cells.Cell Viability Assay Cell Line:The human HCT15, HCT116, and LoVo colon cancer cell lines Concentration:0, 2.5, 5, 10, 20, 40, and 80 μM Incubation Time:24 hours Result:The GI50s on HCT15 and LoVo cells were 34.8±0.07 and 17.9±0.07 μM, and the GI50 on HCT116 cells was >80 μM.

Antroquinonol is a major active component of a mushroom, namely Antrodia camphorate, and it has inhibitory effects on nitric oxide production and inflammatory reactions.Antroq ameliorates proteinuria, improves renal function, and decreases renal lesions, including EPHL, a severe index of glomerular injury, in FSGS mice.Animal Model:8-week-old female BALB/c mice Dosage:50 mg/kg Administration:Given daily by gavage until sacrifice Result:Disease-control FSGS mice treated with vehicle showed increased urine protein levels from day 7 after induction of FSGS that continued to increase to the end of the study at day 21. This effect was almost completely suppressed in FSGS mice treated with Antroq, their levels being similar to those in normal control mice.

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Others

Other Targets

Reactive Oxygen Species | Nrf2

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1010081-09-0

390.56

C24H38O4

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (256.04 mM; 超声助溶 )

C(/C=C(/CC/C=C(/CCC=C(C)C)\C)\C)[C@H]1[C@@H](O)C(OC)=C(OC)C(=O)[C@@H]1C

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(-20℃)

With Ice Pack

≥ 2 years