Anastrozole

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Anastrozole(ZD1033) 是一种有效的、高选择性的芳香酶 (CYP19) 抑制剂 (IC50 = 15 nM)。

Anastrozole(ZD1033) is a potent and highly selective aromatase (CYP19) inhibitor (IC50 = 15 nM) that has no discernible effect on adrenocorticoid hormone synthesis. (In Vitro):Anastrozole is a comparatively simple, achiral benzyltriazole derivative, that inhibits human placental aromatase with an IC50 of 15 nM. In the same assay it is 200 times as potent as aminoglutethimide (AG), twice as potent as 4-OHA and one third as potent as Fadrozole.(In Vivo):Groups of eight immature (22-day-old) female rats are given androstenedione (AD) (30 mg/kg) in arachis oil s.c. daily for 3 days with or without various doses of Anastrozole p.o. on day 4 the uteri are dissected, blotted and weighed. An oral dose of 0.1 mg/kg of Anastrozole given on day 2 or day 3 of the cycle completely blocked ovulation. At the same daily dosage (0.1 mg/kg), Anastrozole completely extinguished the uterotrophic activity of exogenous AD in immature rats. In male pigtailed monkeys, twice-daily oral treatment with 0.1 mg/kg and above of Anastrozole reduced circulating oestradiol concentrations by 50-60%.

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Anastrol | ICI-D 1033 | ZD 1033

Endocrinology/Hormones

Aromatase

Aromatase

Cancer

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120511-73-1

293.37

C17H19N5

>98% (HPLC)

Ethanol: 59 mg/mL (201.11 mM); DMSO: 59 mg/mL (201.11 mM)

CC(C1=CC(CN2N=CN=C2)=CC(C(C)(C)C#N)=C1)(C)C#N

2,2'-(5-((1H-1,2,4-triazol-1-yl)methyl)-1,3-phenylene)bis(2-methylpropanenitrile)

(-20℃)

With Ice Pack

≥ 2 years