Amodiaquine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

阿莫地喹是一种合成氨基喹啉，用于治疗疟疾。

Amodiaquine is a synthetic aminoquinoline used to treat malaria.(In Vitro):Amodiaquine (10-20 μM; 4 hours) treatment suppresses LPS-induced expression of proinflammatory cytokines (IL-1β, interleukin-6, TNF-α and iNOS) in a dose-dependent manner.Amodiaquine (5 μM; 24 hours) significantly inhibits neurotoxin (6-OHDA-induced cell death in primary dopamine cells as examined by the number of TH+ neurons and dopamine uptake. The neuroprotective effect of Amodiaquine is also observed in rat PC12 cells.(In Vivo):Amodiaquine (40 mg/kg; intraperitoneal injection; daily; for 3 days; male ICR mice) treatment diminishes perihematomal activation of microglia/macrophages and astrocytes. Amodiaquine also suppresses ICH-induced mRNA expression of IL-1β, CCL2 and CXCL2, and ameliorated motor dysfunction of mice.

Amodiaquine (10-20 μM; 4 hours) treatment suppresses LPS-induced expression of proinflammatory cytokines (IL-1β, interleukin-6, TNF-α and iNOS) in a dose-dependent manner.Amodiaquine (5 μM; 24 hours) significantly inhibits neurotoxin (6-OHDA-induced cell death in primary dopamine cells as examined by the number of TH+ neurons and dopamine uptake. The neuroprotective effect of Amodiaquine is also observed in rat PC12 cells. RT-PCR Cell Line:Primary microglia Concentration:10 μM, 15 μM, 20 μM Incubation Time:4 hours Result:Suppressed LPS-induced expression of proinflammatory cytokines (IL-1β, interleukin-6, TNF-α and iNOS) in a dose-dependent manner.

Amodiaquine (40 mg/kg; intraperitoneal injection; daily; for 3 days; male ICR mice) treatment diminishes perihematomal activation of microglia/macrophages and astrocytes. Amodiaquine also suppresses ICH-induced mRNA expression of IL-1β, CCL2 and CXCL2, and ameliorated motor dysfunction of mice. Animal Model:Male ICR mice (8-10?weeks of age) induced ntracerebral hemorrhage (ICH) Dosage:40 mg/kg Administration: Intraperitoneal injection; daily; for 3 daysResult:Diminished perihematomal activation of microglia/macrophages and astrocytes.

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Others

Other Targets

Nurr1

Infection

Malaria

86-42-0

355.86

C20H22ClN3O

>98% (HPLC)

DMSO:71 mg/mL (199.52 mM)

CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O

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(-20℃)

With Ice Pack

≥ 2 years