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Aminoxyrone
CAS No. ——
Aminoxyrone ( —— )
产品货号. M17004 CAS No. ——
Aminoxyrone 是一种新型肽组学 C 端 HSP90 抑制剂，通过 C 端结构域 (CTD) 靶向 HSP90 二聚化，Kd 为 27.4 uM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Aminoxyrone
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Aminoxyrone 是一种新型肽组学 C 端 HSP90 抑制剂，通过 C 端结构域 (CTD) 靶向 HSP90 二聚化，Kd 为 27.4 uM。
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产品描述Aminoxyrone is a novel peptidometic C-terminal HSP90 inhibitor by targeting HSP90 dimerization via the C-terminal domain (CTD) with Kd of 27.4 uM; destabilizes BCR-ABL1 without inducing HSR in vitro and in vivo, additionally reduces pAKT-S473, pS6 expression and expression of client proteins associated with HSP90 chaperone activity, involving t-AKT, t-STAT5a, t-CRKL, cMYC, and BCL2; triggers the degradation of HSP90 client proteins without elevating the expression of HSPs (HSP70, HSP40 & HSP27); significantly inhibits cell growth and induces apoptosis of human leukemic stem cells (LSCs) with average EC50 of 20.94 uM, Aminoxyrone is effective in imatinib resistant CML and lacks heat shock response.
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体外实验——
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体内实验——
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同义词——
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通路Cytoskeleton/Cell Adhesion Molecules
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靶点HSP
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受体HSP
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研究领域——
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适应症——
化学信息
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CAS Number——
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分子量994.153
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分子式C50H71N7O14
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纯度>98% (HPLC)
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溶解度——
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SMILES——
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化学全称benzyl (((2R,6R,10R,14R,18R,22R)-6-benzyl-10,14-di((S)-sec-butyl)-22-carbamoyl-18-isobutyl-24-methyl-3,7,11,15,19-pentaoxo-1-phenyl-5,9,13,17,21-pentaoxa-4,8,12,16,20-pentaazapentacosan-2-yl)oxy)carbamate
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Bhatia S, et al. Blood. 2018 May 3. pii: blood-2017-10-810986.
