Allopurinol

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Allopurinol (Zyloprim) 是一种黄嘌呤氧化酶抑制剂，IC50 为 7.82±0.12 μM。

Allopurinol (Zyloprim) is a?xanthine oxidase?inhibitor with an?IC50?of 7.82±0.12 μM.(In Vitro):Allopurinol (0, 10, 100, 1000 μg/ml; 17 h) decreases the expression of HIF-1α and HIF-2α protein in HFF and HUVEC cells.Allopurinol (0, 10, 100, 1000 μg/ml; 24 h) reduces angiogenesis traits of HUVEC cells. (In Vivo):Allopurinol (39 mg/kg; p.o.; daily for 21 successive days) shows anti-depressant activity in mouse.Allopurinol (10-400 mg/kg; i.p.) induces anti-nociception activity in mouse.

Allopurinol (0, 10, 100, 1000 μg/ml; 17 h) decreases the expression of HIF-1α and HIF-2α protein in HFF and HUVEC cells.Allopurinol (0, 10, 100, 1000 μg/ml; 24 h) reduces angiogenesis traits of HUVEC cells.Western Blot Analysis Cell Line:HFF, HUVEC cells Concentration:0, 10, 100, 1000 μg/ml Incubation Time:17 h Result:Reduced HIF-1α and HIF-2α protein expression in a dose dependent manner.

Allopurinol (39 mg/kg; p.o.; daily for 21 successive days) shows anti-depressant activity in mouse.Allopurinol (10-400 mg/kg; i.p.) induces anti-nociception activity in mouse. Animal Model:20-30 g, male Swiss Albino mice Dosage:39 mg/kg Administration:P.o.; daily for 21 successive days Result:Reduced the immobility time in the FST with the immobility time of 129.8±10.5 s.Animal Model:30-40 g, male adult Swiss albino mice Dosage:10, 50, 100, 200, 400 mg/kg Administration:I.p.Result:Produced dose-dependent anti-nociception in the tail-flick, hot-plate.

Allopurinol | Zyloprim | Lopurin | Zyloric | Allohexal | Allohexan

Immunology/Inflammation

ROS

XO

Metabolic Disease

——

315-30-0

136.11

C5H4N4O

>98% (HPLC)

Ethanol: 3 mg/mL (22.04 mM); Water: 4 mg/mL (29.38 mM); DMSO: 27 mg/mL (198.36 mM)

C1=C2C(=NC=NC2=O)NN1

1,2-dihydropyrazolo[3,4-d]pyrimidin-4-one

(-20℃)

With Ice Pack

≥ 2 years