Adarotene

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Adarotene is an effective apoptosis inducer. It surprisingly produces DNA damage and exhibits a potent antiproliferative activity on a large panel of human tumor cells.

Adarotene is an effective apoptosis inducer. It surprisingly produces DNA damage and exhibits a potent antiproliferative activity on a large panel of human tumor cells.(In Vitro):Adarotene causes cell accumulation in the G1/S or S phase of the cell cycle depending on tumor cells IGROV-1 and DU145. Adarotene causes dose-dependent growth inhibition in a large panel of human tumor cell lines with IC50 ranging from 0.1 to 0.3 μM . Adarotene is apoptotic and cytotoxic on a large spectrum of cancerous and leukemic cells, including freshly isolated AML blasts in primary culture. Adarotene treatment of cells results in rapid accumulation of intracellular calcium .(In Vivo):Adarotene (30, 40 mg/kg, p.o.) results in a significant and dose-dependent increase in the life span of NB4-bearing SCID mice without overt toxicity . Adarotene (15, 20 mg/kg, p.o.) causes a significant tumor growth inhibition in a human ovarian carcinoma, A2780/DX, and in human melanoma, MeWo, growing in nude mice .

ST1926

Apoptosis

Apoptosis

Antibiotic; Bacterial; Fungal; Parasite; Phosphatase

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496868-77-0

374.5

C25H26O3

>98% (HPLC)

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OC(=O)\C=C\c1ccc(cc1)-c1ccc(O)c(c1)C12CC3CC(CC(C3)C1)C2

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(-20℃)

With Ice Pack

≥ 2 years