Acebilustat ( CTX-4430;EP-501 )

产品货号. M16760 CAS No. 943764-99-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

拼团产品询价大包装询价加入购物车

产品名称

Acebilustat
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Acebilustat (CTX-4430, EP-501)is a potent and selective leukotriene A4 hydrolase (LTA4H) inhibitor with IC50 of 64 nM for inhibition of LTB4 production in human whole blood.
产品描述

Acebilustat (CTX-4430, EP-501)is a potent and selective leukotriene A4 hydrolase (LTA4H) inhibitor with IC50 of 64 nM for inhibition of LTB4 production in human whole blood; a new once‐daily oral antiinflammatory drug in development for treatment of cystic fibrosis (CF) and other diseases.Cystic Fibrosis,Phase 2 Clinical
同义词

CTX-4430;EP-501
通路

Others
靶点

Other Targets
受体

LTB4
研究领域

Other Indications
适应症

Fibrosis

CAS Number

943764-99-6
分子量

481.54
分子式

C29H27N3O4
纯度

>98% (HPLC)
溶解度

10 mM in DMSO; Methanol: ≥ 32 mg/mL
SMILES

O=C(O)C1=CC=C(CN2[C@](C3)([H])CN(CC4=CC=C(OC5=CC=C(C6=NC=CO6)C=C5)C=C4)[C@]3([H])C2)C=C1
化学全称

Benzoic acid, 4-[[(1S,4S)-5-[[4-[4-(2-oxazolyl)phenoxy]phenyl]methyl]-2,5-diazabicyclo[2.2.1]hept-2-yl]methyl]-

1. Elborn JS, et al. Clin Transl Sci. 2017 Jan;10(1):20-27.
2. Elborn JS, et al. Clin Transl Sci. 2017 Jan;10(1):28-34.

计算器

产品手册

关联产品

Picropodophyllol

Picropodophyllol is a natural product isolated from the roots of Dysosma versipellis.
Methyl nomilinate

Methyl nomilinate from citrus can modulate cell cycle regulators to induce cytotoxicity in human colon cancer (SW480) cells in vitro.
Cassiaglycoside II

Cassiaglycoside II is a natural product for research related to life sciences.