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L189
CAS No. 64232-83-3
L189 ( L189; L 189; L-189 )
产品货号. M18946 CAS No. 64232-83-3
L189 is a human DNA ligase inhibitor, inhibits hLigI/III/IV (IC50: 5/9/5 μM).
纯度: 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥292 | 有现货 |
|
| 5MG | ￥478 | 有现货 |
|
| 10MG | ￥737 | 有现货 |
|
| 25MG | ￥1588 | 有现货 |
|
| 50MG | ￥2778 | 有现货 |
|
| 100MG | ￥3888 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称L189
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述L189 is a human DNA ligase inhibitor, inhibits hLigI/III/IV (IC50: 5/9/5 μM).
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产品描述L189 is a DNA ligase I, III and IV inhibitor (IC50 values are 5, 9 and 5 μM respectively) that blocks DNA binding. L189 inhibits base excision repair (BER) and non-homologous end joining (NHEJ). L189 specifically sensitizes cancer cells to DNA damage and increases the cytotoxicity of DNA-damaging agents. L189 will not only provide insights into the cellular function of these enzymes but also serve as lead compounds for the development of anticancer agents.
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同义词L189; L 189; L-189
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通路Others
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靶点Other Targets
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受体DNA Ligase I; DNA Ligase III; DNA Ligase IV
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研究领域Cancer
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适应症——
化学信息
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CAS Number64232-83-3
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分子量246.29
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分子式C11H10N4OS
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纯度98%
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溶解度DMSO : ≥ 33 mg/mL; 33.99 mM
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SMILESNc1[nH]c(=S)[nH]c(=O)c1\N=C\c1ccccc1
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化学全称(E)-6-amino-5-(benzylideneamino)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Xi Chen, et al. Rational Design of Human DNA Ligase Inhibitors that Target Cellular DNA Replication and Repair. Cancer Res 2008; 68: (9). May 1, 2008.
产品手册
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