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L189

CAS No. 64232-83-3

L189 ( L189; L 189; L-189 )

产品货号. M18946 CAS No. 64232-83-3

L189 is a human DNA ligase inhibitor, inhibits hLigI/III/IV (IC50: 5/9/5 μM).

纯度: 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥292 有现货
5MG ¥478 有现货
10MG ¥737 有现货
25MG ¥1588 有现货
50MG ¥2778 有现货
100MG ¥3888 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    L189
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    L189 is a human DNA ligase inhibitor, inhibits hLigI/III/IV (IC50: 5/9/5 μM).
  • 产品描述
    L189 is a DNA ligase I, III and IV inhibitor (IC50 values are 5, 9 and 5 μM respectively) that blocks DNA binding. L189 inhibits base excision repair (BER) and non-homologous end joining (NHEJ). L189 specifically sensitizes cancer cells to DNA damage and increases the cytotoxicity of DNA-damaging agents. L189 will not only provide insights into the cellular function of these enzymes but also serve as lead compounds for the development of anticancer agents.
  • 同义词
    L189; L 189; L-189
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    DNA Ligase I; DNA Ligase III; DNA Ligase IV
  • 研究领域
    Cancer
  • 适应症
    ——

化学信息

  • CAS Number
    64232-83-3
  • 分子量
    246.29
  • 分子式
    C11H10N4OS
  • 纯度
    98%
  • 溶解度
    DMSO : ≥ 33 mg/mL; 33.99 mM
  • SMILES
    Nc1[nH]c(=S)[nH]c(=O)c1\N=C\c1ccccc1
  • 化学全称
    (E)-6-amino-5-(benzylideneamino)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Xi Chen, et al. Rational Design of Human DNA Ligase Inhibitors that Target Cellular DNA Replication and Repair. Cancer Res 2008; 68: (9). May 1, 2008.
产品手册
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