Acacetin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Acacetin 具有抗疟原虫活性和抗过氧化活性。

Acacetin has anti-plasmodial activity and anti-peroxidant activity. Also acacetin is an ATP-competitive PI3K inhibitor. And has anti-cancer and antitumor activities, such as prostate cancer, melanoma angiogenesis tumor , via Akt/NF-κB,Stat signaling pathway.Has anti-inflammatory and antiarthritic effects in FLSs, can inhibit p38 and JNK phosphorylation and reduces MMP-1, MMP-3 and MMP-13 expression in interleukin-1β-induced FLSs.

Acacetin (5,7-Dihydroxy-4'-methoxyflavone; 10-200 μM; 24 hours) decreases cell viabilities in a dose-dependent manner. Acacetin has little effect on human normal glial cell line HEB and non-tumorigenic epithelial cell line MCF-10A. Acacetin (50-150 μM; 24 hours) causes G2/M cell cycle arrest and induces apoptosis and autophagy.Acacetin (50-150 μM; 24 hours) leads to decreases in levels of PI3Kγ-p110, p-AKT, p-mTOR, p-p70S6K, and p-ULK in a dose-dependent manner. Cell Viability Assay Cell Line:Breast cancer MCF-7 cells, hepatocellular carcinoma SMMC-7721 cells, lung adenocarcinoma A549 cells, esophageal carcinoma Eca109 cells Concentration:10, 20, 40, 60, 80, 100, 150, 200 μM Incubation Time:24 hours Result:Decreased cancer cell viabilities in a dose-dependent manner. Had IC50 values of 82.75?μM, 103.9 μM, 157.4 μM, 54.7 μM in MDA-MB-231, MCF-7, A549, Eca109 cells, respectively.Cell Cycle Analysis Cell Line:MDA-MB-231 cells Concentration:50, 100, 150 μM Incubation Time:24 hours Result:Resulted in increase in percentage of cells at G2/M phase and decrease in percentage of cells at G1 and S phase in a dose-dependent manner.Apoptosis Analysis Cell Line:MDA-MB-231 cells Concentration:50, 100, 150 μMIncubation Time:24 hours Result:Induced apoptosis. Cell Autophagy Assay Cell Line:MDA-MB-231 cells Concentration:50, 100, 150 μM Incubation Time:24 hours Result:Induced autophagy. Resulted in marked increases in EGFP-LC3 puncta formation and a dose-dependent accumulation of LC3-II.Western Blot Analysis Cell Line:MDA-MB-231 cells Concentration:50, 100, 150 μM Incubation Time:24 hours Result:Resulted in decrease in levels of Bcl-2 and Bcl-xL and increase in levels of p53. Led to decreases in levels of PI3Kγ-p110, p-AKT, p-mTOR, p-p70S6K, and p-ULK in a dose-dependent manner.

Acacetin (5,7-Dihydroxy-4'-methoxyflavone; 5, 20 mg/kg/day; orally; for 3 days) significantly suppresses microglial activation in an LPS-induced neuroinflammation mouse model. Acacetin (25 mg/kg/day; orally; for 3 days) reduces neuronal cell death in an animal model of ischemia. Acacetin (1.8-56.2 mg/kg/day; ip; single dose) decreases visceral and inflammatory nociception and prevented the formalin-induced oedema. Animal Model:Male C57BL/6 mice, 7 weeks of age Dosage:5, 20 mg/kg Administration:Orally; once a day for 3 days Result:Significantly suppressed microglial activation in an LPS-induced (ip; 5mg/kg) neuroinflammation mouse model.

LY064233 | NSC 76061

Chromatin/Epigenetic

COX

COX-2| XIAP

Other Indications

——

480-44-4

284.3

C16H12O5

>98% (HPLC)

DMSO: >10.7mg/mL

O=C1C=C(C2=CC=C(OC)C=C2)OC3=C1C(O)=CC(O)=C3

5,7-dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one

(-20℃)

With Ice Pack

≥ 2 years