Abamectin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

阿维菌素 B1（阿维菌素）是一种广泛使用的杀虫剂和驱虫药。

Avermectin B1 (Abamectin) is a widely used insecticide and anthelmintic.

Cell Viability Assay Cell Line:Mouse embryonic fibroblast (MEF) cells Concentration:0, 0.5, 5, 10, 20, 40, 80 μM Incubation Time:12 h Result:Reduced cell viability with an IC50 value of 45.6 μM.Western Blot Analysis Cell Line:MGC803 cells Concentration:0-4 μM Incubation Time:24 h Result:Increased active caspase-3 and expression of Bax/Bcl-2, decreased MMP in a dose-dependent manner.

Animal Model:Horses (had a pruritic dermatosis)Dosage:0.2 mg/kg, a single dose.Administration:Oral administration Result:Decreased in mean strongyle egg counts 14, 28 and 42 d after treatment, and resulted in zero microfilaria counts in all horses 14 d after treatment.Animal Model:Healthy adult female sheep (Pharmacokinetic assay)Dosage:0.2 mg/kg Administration:Subcutaneous administration (in the left neck area of each sheep)Result:Pharmacokinetic profiles of Avermectin B1.

Abamectin, Affirm, Avid, Avid EC, Avomec, EPA Pesticide Chemical Code 122804, HSDB 6941, MK 0936

Others

Other Targets

Antiparasitic

Infection

——

71751-41-2

873.09

C48H72O14

>98% (HPLC)

DMSO: 10 mM

C[C@H]1[C@H](O)[C@@H](OC)C[C@H](O[C@H]2[C@H](C)O[C@@H](O[C@@H]([C@@H](C)/C=C/C=C3CO[C@@]4([H])[C@]\3(O)[C@@]5([H])C=C(C)[C@H]4O)/C(C)=C/C[C@]6([H])C[C@H](OC5=O)C[C@@]7(O[C@H](C(C)C)[C@@H](C)C=C7)O6)C[C@@H]2OC)O1.C[C@H]8[C@H](O)[C@@H](OC)C[C@H](O[C@H]9[C@H](C)O[C@@H](O[C@@H]([C@@H](C)/C=C/C=C%10CO[C@@]%11([H])[C@]\%10(O)[C@@]%12([H])C=C(C)[C@H]%11O)/C(C)=C/C[C@]%13([H])C[C@H](OC%12=O)C[C@@]%14(O[C@H]([C@@H](CC)C)[C@@H](C)C=C%14)O%13)C[C@@H]9OC)O8

Avermectin B(sub 1)

(-20℃)

With Ice Pack

≥ 2 years