GNF351

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

GNF351 是芳烃受体 (AHR) 的完全拮抗剂，能够抑制 DRE 依赖性和非依赖性活性。 GNF351 对小鼠或人类角质形成细胞的毒性极小。

GNF351 is a full antagonist of the aryl hydrocarbon receptor (AHR)with the capacity to inhibit both DRE-dependent and -independent activity.?GNF351 is minimal toxicity in mouse or human keratinocytes.?GNF351 competes with a photoaffinity AHR ligand for binding to the AHR (IC50: 62 nM).?After treating proliferating monolayer cultures of human keratinocytes, GNF351 (500 nM, 48 hours) obviously decreases the percentage of Ki67-positive cells and cell number.

Cell Proliferation Assay Cell Line:Human primary keratinocytes Concentration:500 nM Incubation Time:48 hours Result:Showed a significant reduction in the percentage of Ki67-positive cells and cell number after treating proliferating monolayer cultures of human keratinocytes for 48 hours.

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Others

Other Targets

aryl hydrocarbon receptor

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1227634-69-6

411.50

C24H25N7

>98% (HPLC)

DMSO:124 mg/mL(301.34 mM)

CC(C)n1cnc2c(NCCc3c[nH]c4ccccc34)nc(nc12)-c1cncc(C)c1

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(-20℃)

With Ice Pack

≥ 2 years