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GNF351
CAS No. 1227634-69-6
GNF351 ( —— )
产品货号. M22680 CAS No. 1227634-69-6
GNF351 is a full antagonist of the aryl hydrocarbon receptor (AHR)with the capacity to inhibit both DRE-dependent and -independent activity.?GNF351 is minimal toxicity in mouse or human keratinocytes.?
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥697 | 有现货 |
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| 10MG | ￥1191 | 有现货 |
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| 25MG | ￥2406 | 有现货 |
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| 50MG | ￥4431 | 有现货 |
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| 100MG | ￥5962 | 有现货 |
|
| 200MG | ￥8060 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称GNF351
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述GNF351 is a full antagonist of the aryl hydrocarbon receptor (AHR)with the capacity to inhibit both DRE-dependent and -independent activity.?GNF351 is minimal toxicity in mouse or human keratinocytes.?
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产品描述GNF351 is a full antagonist of the aryl hydrocarbon receptor (AHR)with the capacity to inhibit both DRE-dependent and -independent activity.?GNF351 is minimal toxicity in mouse or human keratinocytes.?GNF351 competes with a photoaffinity AHR ligand for binding to the AHR (IC50: 62 nM).?After treating proliferating monolayer cultures of human keratinocytes, GNF351 (500 nM, 48 hours) obviously decreases the percentage of Ki67-positive cells and cell number.
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同义词——
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通路Others
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靶点Other Targets
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受体aryl hydrocarbon receptor
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研究领域——
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适应症——
化学信息
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CAS Number1227634-69-6
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分子量411.5
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分子式C24H25N7
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纯度>98% (HPLC)
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溶解度DMSO:124 mg/mL(301.34 mM)
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SMILESCC(C)n1cnc2c(NCCc3c[nH]c4ccccc34)nc(nc12)-c1cncc(C)c1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. van den Bogaard EH，et al. Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation. J Invest Dermatol. 2015 May;135(5):1320-1328.
产品手册
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