
GNF351
CAS No. 1227634-69-6
GNF351 ( —— )
产品货号. M22680 CAS No. 1227634-69-6
GNF351 是芳烃受体 (AHR) 的完全拮抗剂,能够抑制 DRE 依赖性和非依赖性活性。 GNF351 对小鼠或人类角质形成细胞的毒性极小。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥697 | 有现货 |
![]() ![]() |
10MG | ¥1191 | 有现货 |
![]() ![]() |
25MG | ¥2406 | 有现货 |
![]() ![]() |
50MG | ¥4431 | 有现货 |
![]() ![]() |
100MG | ¥5962 | 有现货 |
![]() ![]() |
200MG | ¥8060 | 有现货 |
![]() ![]() |
500MG | 获取报价 | 有现货 |
![]() ![]() |
1G | 获取报价 | 有现货 |
![]() ![]() |
生物学信息
-
产品名称GNF351
-
注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
-
产品简述GNF351 是芳烃受体 (AHR) 的完全拮抗剂,能够抑制 DRE 依赖性和非依赖性活性。 GNF351 对小鼠或人类角质形成细胞的毒性极小。
-
产品描述GNF351 is a full antagonist of the aryl hydrocarbon receptor (AHR)with the capacity to inhibit both DRE-dependent and -independent activity.?GNF351 is minimal toxicity in mouse or human keratinocytes.?GNF351 competes with a photoaffinity AHR ligand for binding to the AHR (IC50: 62 nM).?After treating proliferating monolayer cultures of human keratinocytes, GNF351 (500 nM, 48 hours) obviously decreases the percentage of Ki67-positive cells and cell number.
-
体外实验Cell Proliferation Assay Cell Line:Human primary keratinocytes Concentration:500 nM Incubation Time:48 hours Result:Showed a significant reduction in the percentage of Ki67-positive cells and cell number after treating proliferating monolayer cultures of human keratinocytes for 48 hours.
-
体内实验——
-
同义词——
-
通路Others
-
靶点Other Targets
-
受体aryl hydrocarbon receptor
-
研究领域——
-
适应症——
化学信息
-
CAS Number1227634-69-6
-
分子量411.50
-
分子式C24H25N7
-
纯度>98% (HPLC)
-
溶解度DMSO:124 mg/mL(301.34 mM)
-
SMILESCC(C)n1cnc2c(NCCc3c[nH]c4ccccc34)nc(nc12)-c1cncc(C)c1
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. van den Bogaard EH,et al. Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation. J Invest Dermatol. 2015 May;135(5):1320-1328.
产品手册




关联产品
-
16-Epikoumidine
16-Epikoumidine is a natural product for research related to life sciences.
-
NVP-ACC789
ACC-789 (NVP-ACC789; ZK-202650) 是一种有效、特异性和口服活性的 VEGF 受体酪氨酸激酶抑制剂。
-
Eicosapentaenoic Aci...
二十碳五烯酸 (EPA) 是海洋生物中含量丰富的 ω-3 脂肪酸。