
AZD1208
CAS No. 1204144-28-4
AZD1208 ( AZD1208 | AZD-1208 )
产品货号. M17879 CAS No. 1204144-28-4
AZD1208 是一种新型、口服生物可利用的、高选择性 PIM 激酶抑制剂,对所有三种 PIM 激酶具有单纳摩尔效力。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥381 | 有现货 |
![]() ![]() |
10MG | ¥551 | 有现货 |
![]() ![]() |
25MG | ¥980 | 有现货 |
![]() ![]() |
50MG | ¥1823 | 有现货 |
![]() ![]() |
100MG | ¥3216 | 有现货 |
![]() ![]() |
200MG | ¥4228 | 有现货 |
![]() ![]() |
500MG | ¥6747 | 有现货 |
![]() ![]() |
1G | 获取报价 | 有现货 |
![]() ![]() |
生物学信息
-
产品名称AZD1208
-
注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
-
产品简述AZD1208 是一种新型、口服生物可利用的、高选择性 PIM 激酶抑制剂,对所有三种 PIM 激酶具有单纳摩尔效力。
-
产品描述AZD1208 is orally available, small molecule inhibitor of PIM kinases with potential antineoplastic activity. Pan-PIM kinase inhibitor AZD1208 inhibits the activities of PIM1, PIM2 and PIM3 serine/threonine kinases, which may result in the interruption of the G1/S phase cell cycle transition, thereby causing cell cycle arrest and inducing apoptosis in cells that overexpress PIMs. The growth inhibition of several leukemia cell lines by this agent is correlated with the expression levels of PIM1, which is the substrate of STAT transcription factors. PIM kinases are downstream effectors of many cytokine and growth factor signaling pathways and are upregulated in various malignancies.
-
体外实验——
-
体内实验——
-
同义词AZD1208 | AZD-1208
-
通路Others
-
靶点Other Targets
-
受体Pim1| Pim2| Pim3
-
研究领域Cancer
-
适应症——
化学信息
-
CAS Number1204144-28-4
-
分子量379.48
-
分子式C21H21N3O2S
-
纯度>98% (HPLC)
-
溶解度DMSO : 28.5 mg/mL 75.10 mM;
-
SMILESc1(c(cccc1/C=C/1\SC(=O)NC1=O)c1ccccc1)N1CCC[C@H](C1)N
-
化学全称5-[[2-[(3R)-3-Aminopiperidin-1-yl]biphenyl-3-yl]methylidene]-1,3-thiazolidine-2,4-dione
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Kirschner AN, et al. J Natl Y Inst. 2014 Dec 13;107(2) 2. Keeton EK, et al.Blood. 2014 Feb 6;123(6):905-13..
产品手册




关联产品
-
Adrenomedullin (AM) ...
Adrenomedullin (AM) (1-52), human is a 52-amino acid peptide, which affects cell proliferation and angiogenesis in cancer.
-
SPQ
SPQ 用于测量膜氯离子传输机制。
-
Gluconapin
The seeds of Lepidium apetalum.