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AX20017

CAS No. 329221-38-7

AX20017 ( —— )

产品货号. M20738 CAS No. 329221-38-7

AX20017 是一种小分子蛋白激酶 G (PknG) 抑制剂 (IC50 : 0.39 μM)。它通过阻止结核分枝杆菌的增殖发挥作用。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥348 有现货
5MG ¥527 有现货
10MG ¥745 有现货
25MG ¥1604 有现货
50MG ¥2778 有现货
100MG ¥4180 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    AX20017
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    AX20017 是一种小分子蛋白激酶 G (PknG) 抑制剂 (IC50 : 0.39 μM)。它通过阻止结核分枝杆菌的增殖发挥作用。
  • 产品描述
    AX20017 is a small-molecule protein kinase G (PknG) inhibitor(IC50 : 0.39 μM). It acts by blocking the proliferation of M. tuberculosis.(In Vitro):The compound AX20017 inhibitor is bound deep within a narrow pocket formed by the inter lobe cleft of the PknG domain. The main chain Glu233:O and Val235:NH of PknG form hydrogen bonds with AX20017.AX20017 results in mycobacterial transfer to lysosomes and killing of the mycobacteria. AX20017 does not affect the human kinases, whereas the activity of PknG is effectively inhibited. AX20017 does not affect cellular morphology, membrane ruffling, or macropinocytosis.
  • 体外实验
    The compound AX20017 inhibitor is bound deep within a narrow pocket formed by the inter lobe cleft of the PknG domain. The main chain Glu233:O and Val235:NH of PknG form hydrogen bonds with AX20017.AX20017 results in mycobacterial transfer to lysosomes and killing of the mycobacteria. AX20017 does not affect the human kinases, whereas the activity of PknG is effectively inhibited. AX20017 does not affect cellular morphology, membrane ruffling, or macropinocytosis.
  • 体内实验
    ——
  • 同义词
    ——
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    PknG
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    329221-38-7
  • 分子量
    264.34
  • 分子式
    C13H16N2O2S
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO:32 mg/mL (121.06 mM)
  • SMILES
    NC(=O)c1c(NC(=O)C2CC2)sc2CCCCc12
  • 化学全称
    2-(Cyclopropanecarbonylamino)-233a45677a-octahydro-1-benzothiophene-3-carboxamide

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Scherr N Honnappa S Kunz G et al. Structural basis for the specific inhibition of protein kinase G a virulence factor of Mycobacterium tuberculosis[J]. Proceedings of the National Academy of Sciences 2007 104(29):12151-12156.
产品手册
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