AX20017

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

AX20017 是一种小分子蛋白激酶 G (PknG) 抑制剂 (IC50 : 0.39 μM)。它通过阻止结核分枝杆菌的增殖发挥作用。

AX20017 is a small-molecule protein kinase G (PknG) inhibitor(IC50 : 0.39 μM). It acts by blocking the proliferation of M. tuberculosis.(In Vitro):The compound AX20017 inhibitor is bound deep within a narrow pocket formed by the inter lobe cleft of the PknG domain. The main chain Glu233:O and Val235:NH of PknG form hydrogen bonds with AX20017.AX20017 results in mycobacterial transfer to lysosomes and killing of the mycobacteria. AX20017 does not affect the human kinases, whereas the activity of PknG is effectively inhibited. AX20017 does not affect cellular morphology, membrane ruffling, or macropinocytosis.

The compound AX20017 inhibitor is bound deep within a narrow pocket formed by the inter lobe cleft of the PknG domain. The main chain Glu233:O and Val235:NH of PknG form hydrogen bonds with AX20017.AX20017 results in mycobacterial transfer to lysosomes and killing of the mycobacteria. AX20017 does not affect the human kinases, whereas the activity of PknG is effectively inhibited. AX20017 does not affect cellular morphology, membrane ruffling, or macropinocytosis.

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Others

Other Targets

PknG

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329221-38-7

264.34

C13H16N2O2S

>98% (HPLC)

DMSO:32 mg/mL (121.06 mM)

NC(=O)c1c(NC(=O)C2CC2)sc2CCCCc12

2-(Cyclopropanecarbonylamino)-233a45677a-octahydro-1-benzothiophene-3-carboxamide

(-20℃)

With Ice Pack

≥ 2 years