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AVN-101

CAS No. 1025725-91-0

AVN-101 ( AVN101 )

产品货号. M10121 CAS No. 1025725-91-0

A higly potent, orally bioavailable, BBB permeable 5-HT7 receptor antagonist with Ki of 153 pM, with slightly lesser potency toward 5-HT6, 5-HT2A and 5HT-2C (Ki=1.2-2.0 nM).

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥7857 有现货
50MG ¥16038 有现货
100MG ¥20250 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    AVN-101
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    A higly potent, orally bioavailable, BBB permeable 5-HT7 receptor antagonist with Ki of 153 pM, with slightly lesser potency toward 5-HT6, 5-HT2A and 5HT-2C (Ki=1.2-2.0 nM).
  • 产品描述
    A higly potent, orally bioavailable, BBB permeable 5-HT7 receptor antagonist with Ki of 153 pM, with slightly lesser potency toward 5-HT6, 5-HT2A and 5HT-2C (Ki=1.2-2.0 nM); also exhibits a rather high affinity toward histamine H1 (Ki=0.58nM) and adrenergic α2A, α2B, and α2C (Ki=0.41-3.6nM) receptors; demonstrates reasonable anxiolytic and anti-depressive activities in animal models of CNS diseases with low safety concerns.Anxiety Phase 2 Clinical
  • 同义词
    AVN101
  • 通路
    Endocrinology/Hormones
  • 靶点
    5-HT Receptor
  • 受体
    5-HT Receptor
  • 研究领域
    Neurological Disease
  • 适应症
    Anxiety

化学信息

  • CAS Number
    1025725-91-0
  • 分子量
    304.44
  • 分子式
    C21H24N2
  • 纯度
    >98% (HPLC)
  • 溶解度
    ——
  • SMILES
    CC1=CC2=C(C=C1)N(C3=C2CN(CC3)C)CCC4=CC=CC=C4
  • 化学全称
    2,8-dimethyl-5-phenethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Ivachtchenko AV, et al. J Alzheimers Dis. 2016 May 25;53(2):583-620.
产品手册
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