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AVN-101
CAS No. 1025725-91-0
AVN-101 ( AVN101 )
产品货号. M10121 CAS No. 1025725-91-0
A higly potent, orally bioavailable, BBB permeable 5-HT7 receptor antagonist with Ki of 153 pM, with slightly lesser potency toward 5-HT6, 5-HT2A and 5HT-2C (Ki=1.2-2.0 nM).
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥7857 | 有现货 |
|
| 50MG | ￥16038 | 有现货 |
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| 100MG | ￥20250 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称AVN-101
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述A higly potent, orally bioavailable, BBB permeable 5-HT7 receptor antagonist with Ki of 153 pM, with slightly lesser potency toward 5-HT6, 5-HT2A and 5HT-2C (Ki=1.2-2.0 nM).
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产品描述A higly potent, orally bioavailable, BBB permeable 5-HT7 receptor antagonist with Ki of 153 pM, with slightly lesser potency toward 5-HT6, 5-HT2A and 5HT-2C (Ki=1.2-2.0 nM); also exhibits a rather high affinity toward histamine H1 (Ki=0.58nM) and adrenergic α2A, α2B, and α2C (Ki=0.41-3.6nM) receptors; demonstrates reasonable anxiolytic and anti-depressive activities in animal models of CNS diseases with low safety concerns.Anxiety Phase 2 Clinical
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同义词AVN101
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通路Endocrinology/Hormones
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靶点5-HT Receptor
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受体5-HT Receptor
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研究领域Neurological Disease
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适应症Anxiety
化学信息
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CAS Number1025725-91-0
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分子量304.44
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分子式C21H24N2
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纯度>98% (HPLC)
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溶解度——
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SMILESCC1=CC2=C(C=C1)N(C3=C2CN(CC3)C)CCC4=CC=CC=C4
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化学全称2,8-dimethyl-5-phenethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Ivachtchenko AV, et al. J Alzheimers Dis. 2016 May 25;53(2):583-620.
产品手册
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