AUTEN-67 ( Autophagy Enhancer 67;AUTEN67 )

产品货号. M12684 CAS No. 1783800-77-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

AUTEN-67
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

A small molecule autophagy enhancer that specificly inhibits myotubularin-related phosphatase MTMR14; at concentrations of 2, 10, and 100 uM, AUTEN-67 inhibits MTMR14 by nearly 3%, 25%, and 70%, respectively.
产品描述

A small molecule autophagy enhancer that specificly inhibits myotubularin-related phosphatase MTMR14; at concentrations of 2, 10, and 100 uM, AUTEN-67 inhibits MTMR14 by nearly 3%, 25%, and 70%, respectively; shows no activity for CDC25B , other phosphatase, PTPN1; significantly increases autophagic flux in cell lines and in vivo models, promotes longevity and protects neurons from undergoing stress-induced cell death; also restores nesting behavior in a murine model of Alzheimer disease, without apparent side effects.
同义词

Autophagy Enhancer 67;AUTEN67
通路

Autophagy
靶点

Autophagy
受体

Autophagy
研究领域

——
适应症

——

CAS Number

1783800-77-0
分子量

474.45
分子式

C23H14N4O6S
纯度

>98% (HPLC)
溶解度

——
SMILES

C1=CC=C2C(=C1)C(=O)C(=C(C2=O)N3C=NC4=CC=CC=C43)NS(=O)(=O)C5=CC=C(C=C5)[N+](=O)[O-]
化学全称

N-(3-(1H-benzo[d]imidazol-1-yl)-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-nitrobenzenesulfonamide

1. Papp D, et al. Autophagy. 2016;12(2):273-86.
2. Billes V, et al. J Huntingtons Dis. 2016 May 7;5(2):133-47.

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