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ATR-101

CAS No. 133825-81-7

ATR-101 ( PD-132301;PD132301-2;ATR 101;Nevanimibe )

产品货号. M11357 CAS No. 133825-81-7

ATR-101 (PD-132301, Nevanimibe) is a selective and potent inhibitor of ACAT1 with IC50 of 52 nM.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥1725 有现货
10MG ¥2406 有现货
25MG ¥3750 有现货
50MG ¥4795 有现货
100MG ¥6375 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    ATR-101
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    ATR-101 (PD-132301, Nevanimibe) is a selective and potent inhibitor of ACAT1 with IC50 of 52 nM.
  • 产品描述
    ATR-101 (PD-132301, Nevanimibe) is a selective and potent inhibitor of ACAT1 with IC50 of 52 nM; induces H295R cell apoptosis, causes mitochondrial hyperpolarization, reactive oxygen release, and ATP depletion, caspase-3/7 activation, and membrane permeabilization; decreases the formation of cholesteryl esters and increases FC levels in H295R adrenocortical carcinoma cells; inhibits the establishment and impeds the growth of ACC-derived H295R cell xenografts in mice; orally active.Cushing Disease Phase 2 Clinical
  • 同义词
    PD-132301;PD132301-2;ATR 101;Nevanimibe
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Other Targets
  • 研究领域
    Endocrinology
  • 适应症
    Cushing Disease

化学信息

  • CAS Number
    133825-81-7
  • 分子量
    458.09
  • 分子式
    C27H40ClN3O
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO : 41.67 mg/mL. 90.97 mM
  • SMILES
    CC(C)C1=C(C(=CC=C1)C(C)C)NC(=O)NCC2(CCCC2)C3=CC=C(C=C3)N(C)C.Cl
  • 化学全称
    1-(2,6-diisopropylphenyl)-3-((1-(4-(dimethylamino)phenyl)cyclopentyl)methyl)urea hydrochloride

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. LaPensee CR, et al. Endocrinology. 2016 May;157(5):1775-88.
2. Trivedi BK, et al. J Med Chem. 1994 May 27;37(11):1652-9.
3. Cheng Y, et al. Endocr Relat Cancer. 2016 Apr;23(4):1-19.
产品手册
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