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ATR-101
CAS No. 133825-81-7
ATR-101 ( PD-132301;PD132301-2;ATR 101;Nevanimibe )
产品货号. M11357 CAS No. 133825-81-7
ATR-101 (PD-132301, Nevanimibe) is a selective and potent inhibitor of ACAT1 with IC50 of 52 nM.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1725 | 有现货 |
|
| 10MG | ￥2406 | 有现货 |
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| 25MG | ￥3750 | 有现货 |
|
| 50MG | ￥4795 | 有现货 |
|
| 100MG | ￥6375 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称ATR-101
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述ATR-101 (PD-132301, Nevanimibe) is a selective and potent inhibitor of ACAT1 with IC50 of 52 nM.
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产品描述ATR-101 (PD-132301, Nevanimibe) is a selective and potent inhibitor of ACAT1 with IC50 of 52 nM; induces H295R cell apoptosis, causes mitochondrial hyperpolarization, reactive oxygen release, and ATP depletion, caspase-3/7 activation, and membrane permeabilization; decreases the formation of cholesteryl esters and increases FC levels in H295R adrenocortical carcinoma cells; inhibits the establishment and impeds the growth of ACC-derived H295R cell xenografts in mice; orally active.Cushing Disease Phase 2 Clinical
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同义词PD-132301;PD132301-2;ATR 101;Nevanimibe
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通路Others
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靶点Other Targets
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受体Other Targets
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研究领域Endocrinology
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适应症Cushing Disease
化学信息
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CAS Number133825-81-7
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分子量458.09
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分子式C27H40ClN3O
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纯度>98% (HPLC)
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溶解度DMSO : 41.67 mg/mL. 90.97 mM
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SMILESCC(C)C1=C(C(=CC=C1)C(C)C)NC(=O)NCC2(CCCC2)C3=CC=C(C=C3)N(C)C.Cl
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化学全称1-(2,6-diisopropylphenyl)-3-((1-(4-(dimethylamino)phenyl)cyclopentyl)methyl)urea hydrochloride
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
2. Trivedi BK, et al. J Med Chem. 1994 May 27;37(11):1652-9.
3. Cheng Y, et al. Endocr Relat Cancer. 2016 Apr;23(4):1-19.
产品手册
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