
Tolimidone
CAS No. 41964-07-2
Tolimidone ( MLR-1003 | MLR 1003 | MLR1003 | CID-39065 )
产品货号. M18535 CAS No. 41964-07-2
MLR-1023 是一种化合物,可抑制动物模型中的酸分泌,并且还可在组胺攻击的动物中充当支气管扩张剂。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
10MG | ¥567 | 有现货 |
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50MG | ¥1539 | 有现货 |
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100MG | ¥2309 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Tolimidone
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述MLR-1023 是一种化合物,可抑制动物模型中的酸分泌,并且还可在组胺攻击的动物中充当支气管扩张剂。
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产品描述MLR-1003 is a Lyn kinase activator that induces glycemic control.(In Vitro):Incubation of Tolimidone (MLR-1023) with Lyn kinase elicits a repeatable 50% increase in enzyme activity. Tolimidone elicits a concentration-dependent increase in Lyn kinase activation with a 2.3- and 2.1-fold increase achieved at concentrations of 3 and 10 μM, respectively. Inclusion of Tolimidone (100 μM) increases Lyn kinase activity by 3-fold at each ATP concentration tested (Vmax=2601 U/mg). Tolimidone-mediated activation of Lyn kinase increases in proportion to the length of preincubation period in the absence of ATP.(In Vivo):Administration of Tolimidone (MLR-1023) (30 mg/kg i.p.) significantly (p<0.05) lowers blood glucose levels to 148 and 158 mg/dL, 30 and 90 min after administration, respectively. Tolimidone significantly increases adipocyte differentiation and adiponectin production by 3.7- and 19-fold, respectively. Tolimidone elicits a dose-dependent potentiation of the insulin response, with a maximal effect observed with a dose level of 30 mg/kg.
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体外实验Incubation of Tolimidone (MLR-1023) with Lyn kinase elicits a repeatable 50% increase in enzyme activity. Tolimidone elicits a concentration-dependent increase in Lyn kinase activation with a 2.3- and 2.1-fold increase achieved at concentrations of 3 and 10 μM, respectively. Inclusion of Tolimidone (100 μM) increases Lyn kinase activity by 3-fold at each ATP concentration tested (Vmax=2601 U/mg). Tolimidone-mediated activation of Lyn kinase increases in proportion to the length of preincubation period in the absence of ATP.
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体内实验Administration of Tolimidone (MLR-1023) (30 mg/kg i.p.) significantly (p<0.05) lowers blood glucose levels to 148 and 158 mg/dL, 30 and 90 min after administration, respectively. Tolimidone significantly increases adipocyte differentiation and adiponectin production by 3.7- and 19-fold, respectively. Tolimidone elicits a dose-dependent potentiation of the insulin response, with a maximal effect observed with a dose level of 30 mg/kg.
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同义词MLR-1003 | MLR 1003 | MLR1003 | CID-39065
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通路Others
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靶点Other Targets
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受体Lyn kinase
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研究领域Others-Field
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适应症——
化学信息
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CAS Number41964-07-2
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分子量202.21
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分子式C11H10N2O2
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纯度>98% (HPLC)
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溶解度DMSO : 150 mg/mL 741.80 mM
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SMILESCC1=CC=CC(OC2=CNC(=O)N=C2)=C1
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化学全称5-(3-Methylphenoxy)-2(1H)-pyrimidinone
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
产品手册




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