ARN-5187

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

A novel lysosomotropic REV-ERB ligand that has a dual inhibitory activity toward REV-ERB-mediated transcriptional regulation and autophagy.

A novel lysosomotropic REV-ERB ligand that has a dual inhibitory activity toward REV-ERB-mediated transcriptional regulation and autophagy; relieves REV-ERB-mediated transcriptional repression, significantly increases autophagy-associated protein p62 in treated cells; disrupts lysosomal function, blocks the autophagy process at the late stage, and reduces cancer cell viability; a novel dual autophagy/REV-ERB inhibitor more cytotoxic than chloroquine.

ARN5187;ARN 5187

Autophagy

Autophagy

Autophagy

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1287451-26-6

397.54

C24H32FN3O

>98% (HPLC)

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4-[[[1-(2-Fluorophenyl)cyclopentyl]amino]methyl]-2-[(4-methyl-1-piperazinyl)methyl]phenol

(-20℃)

With Ice Pack

≥ 2 years