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AK306
CAS No. ——
AK306 ( AK 306;AK-306 )
产品货号. M16971 CAS No. ——
AK306 is a small molecule clathrin heavy chain (CLTC/CHC) binding compound that induces arrest and apoptosis of the HCT116 colon cancer cell line with EC50 of 50 nM.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
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| 1G | 获取报价 | 有现货 |
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生物学信息
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产品名称AK306
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述AK306 is a small molecule clathrin heavy chain (CLTC/CHC) binding compound that induces arrest and apoptosis of the HCT116 colon cancer cell line with EC50 of 50 nM.
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产品描述AK306 is a small molecule clathrin heavy chain (CLTC/CHC) binding compound that induces arrest and apoptosis of the HCT116 colon cancer cell line with EC50 of 50 nM; demonstrates broad spectrum activity against of cancer cell lines with total growth inhibition values ranging from ~25 nM to 25 uM; disrupts Aurora A localization, leading to the formation of multiple foci, induces a p53-dependent cell death, and centrosome disruption.
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同义词AK 306;AK-306
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通路Others
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靶点Clathrin
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受体Clathrin
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研究领域——
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适应症——
化学信息
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CAS Number——
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分子量379.28
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分子式C19H20Cl2N2O2
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纯度>98% (HPLC)
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溶解度——
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SMILES——
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化学全称(4-(3,5-dichlorophenyl)piperazin-1-yl)(2-ethoxyphenyl)methanone
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Bond MJ, et al. Mol Cancer Res. 2018 May 16. pii: molcanres.0178.2018.
产品手册
关联产品
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Pitstop 2 (b)
A small molecule inhibitor of clathrin terminal domain and inhibits clathrin-mediated endocytosis.
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AK306
AK306 is a small molecule clathrin heavy chain (CLTC/CHC) binding compound that induces arrest and apoptosis of the HCT116 colon cancer cell line with EC50 of 50 nM.
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Pitstop 1
A potent, selective inhibitor of clathrin-independent endocytosis with IC50 of 18 uM.
