AFMK
CAS No. 52450-38-1
AFMK ( Acetyl-N-formyl-5-methoxykynurenamine; Formyl-N-acetyl-5-methoxykynurenamine )
产品货号. M28365 CAS No. 52450-38-1
AFMK is an active metabolite of Melatonin with antioxidant and free radical scavenging activity. AFMK is a modulator of apoptosis and improves the anti-tumor effect of Gemcitabine in PANC-1 cells.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥721 | 有现货 |
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5MG | ¥1037 | 有现货 |
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10MG | ¥1604 | 有现货 |
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25MG | ¥2616 | 有现货 |
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50MG | ¥3880 | 有现货 |
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100MG | ¥5557 | 有现货 |
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500MG | ¥11988 | 有现货 |
|
1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称AFMK
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述AFMK is an active metabolite of Melatonin with antioxidant and free radical scavenging activity. AFMK is a modulator of apoptosis and improves the anti-tumor effect of Gemcitabine in PANC-1 cells.
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产品描述AFMK is an active metabolite of Melatonin with antioxidant and free radical scavenging activity. AFMK is a modulator of apoptosis and improves the anti-tumor effect of Gemcitabine in PANC-1 cells.(In Vitro):In PANC-1 cell, AFMK in combination with Gemcitabine increases the inhibition of the production of HSP70 from 0.47 (Gemcitabine alone) to 0.13 (10 nM AFMK), 0.08 (0.1 nM AFMK) and 0.01 (0.001 nM AFMK). AFMK pretreatment significantly inhibits DNA damage and shows a very high hydroxyl radical scavenging potential with an IC50 of 338.08 nM.(In Vivo):In male C57BL mice, AFMK (10 mg/kg; i.p.) significantly reverses radiation-induced decline in the total antioxidant capacity of plasma. Pretreatment of AFMK shows a significantly lower value of comet tail length and % DNA in tail.
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同义词Acetyl-N-formyl-5-methoxykynurenamine; Formyl-N-acetyl-5-methoxykynurenamine
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通路Apoptosis
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靶点Apoptosis
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受体Human Endogenous Metabolite;Antioxidant;Free radical scavengers;Apoptosis
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研究领域——
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适应症——
化学信息
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CAS Number52450-38-1
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分子量264.3
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分子式C13H16N2O4
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纯度>98% (HPLC)
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溶解度——
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SMILESO=CNC1=CC=C(OC)C=C1C(=O)CCNC(=O)C
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Anna Leja-Szpak, et al. Melatonin and its metabolite N1-acetyl-N2-formyl-5-methoxykynuramine (afmk) enhance chemosensitivity to gemcitabine in pancreatic carcinoma cells (PANC-1). Pharmacol Rep. 2018 Dec;70(6):1079-1088.
产品手册
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