AC-264613 ( AC-264613; AC 264613; AC264613 )

产品货号. M17128 CAS No. 1051487-82-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

AC-264613
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

AC-264613 is an agonist of the GPCR protease-activated receptor 2 (PAR2).
产品描述

AC-264613 is the first agonist of the G-protein-coupled receptor (GPCR) protease activated receptor 2 (PAR2). AC-264613 suppresses interferon regulatory factor 5 and decreases interleukin-12p40 production by lipopolysaccharide-stimulated macrophages. AC-264613 activated PAR2 signaling in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca(2+) mobilization assays, with potencies ranging from 30 to 100 nM.
同义词

AC-264613; AC 264613; AC264613
通路

Others
靶点

Other Targets
受体

PAR-2
研究领域

——
适应症

——

CAS Number

1051487-82-1
分子量

400.28
分子式

C19H18BrN3O2
纯度

98%
溶解度

——
SMILES

O=C([C@H]1C(=O)NC[C@@H]1c1ccccc1)N/N=C(/c1cccc(Br)c1)\C
化学全称

(3R,4S)-rel-2-Oxo-4-phenyl-3-pyrrolidinecarboxylic acid 2-[1-(3-bromophenyl)ethylidene]hydrazide

1.Cosimi E, et al. Stereoselective Synthesis of α-Fluoro-γ-nitro Thioesters under Organocatalytic Conditions. Org Lett. 2016 Dec 2;18(23):6014-6017

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