
Ibrolipim
CAS No. 133208-93-2
Ibrolipim ( NO-1886 )
产品货号. M21132 CAS No. 133208-93-2
Ibrolipim 通过 PI3K/Akt 途径减轻培养的人脐静脉内皮细胞中高葡萄糖诱导的内皮功能障碍。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥348 | 有现货 |
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10MG | ¥624 | 有现货 |
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25MG | ¥948 | 有现货 |
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50MG | ¥1426 | 有现货 |
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100MG | ¥2130 | 有现货 |
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200MG | ¥3208 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Ibrolipim
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Ibrolipim 通过 PI3K/Akt 途径减轻培养的人脐静脉内皮细胞中高葡萄糖诱导的内皮功能障碍。
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产品描述Ibrolipim attenuates high glucose-induced endothelial dysfunction in cultured human umbilical vein endothelial cells via PI3K/Akt pathway.
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体外实验Western Blot Analysis Cell Line:THP-1 macrophage-derived foam cells Concentration:0.5 μM, 5 μM, 10 μM Incubation Time:0 hour, 6 hours, 12 hours, 24 hours Result:Increased ABCA1 and ABCG1 translational levels in a dose-dependent and time-dependent manner.RT-PCR Cell Line:THP-1 macrophage-derived foam cells Concentration:0.5 μM, 5 μM, 10 μM Incubation Time:0 hour, 6 hours, 12 hours, 24 hours Result:Increased ABCA1 and ABCG1 expression at the transcriptional levels in a dose-dependent and time-dependent manner.
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体内实验Animal Model:Female Sprague-Dawley rats (10-week-old; 200-260 g) with experimental ovariectomy treatment Dosage:100 mg/kg Administration:Oral administration; daily; for 8 weeks Result:Decreased accumulation of visceral fat and suppressed the increase in body weight resulting from the ovariectomy.
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同义词NO-1886
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通路Others
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靶点Other Targets
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受体Lipoprotein lipase (LPL)
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研究领域——
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适应症——
化学信息
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CAS Number133208-93-2
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分子量451.25
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分子式Br1C19H20N2O4P1
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纯度>98% (HPLC)
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溶解度DMSO:125 mg/mL (277.01 mM; Need ultrasonic)
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SMILESCCOP(=O)(Cc1ccc(C(=O)Nc2ccc(Br)cc2C#N)cc1)OCC
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化学全称Diethyl (4-((4-bromo-2-cyanophenyl)carbamoyl)benzyl)phosphonate
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Chen SG et al. Ibrolipim increases ABCA1/G1 expression by the LXRα signaling pathway in THP-1 macrophage-derived foam cells. Acta Pharmacol Sin. 2010 Oct;31(10):1343-9.
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