AA-861

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

AA-861 (Docebenone) 是一种有效的选择性 5-脂氧合酶 (5-LO) 抑制剂，IC50 为 0.8 uM。

AA-861 (Docebenone) is a potent, selective 5-Lipoxygenase (5-LO) inhibitor with IC50 of 0.8 uM; induces cytotoxic and anti-proliferative effects in 5-LO-positive Capan-2 pancreatic cancer cells; also efficiently inhibits biofilms by preventing the formation of amyloid-like fibers.Allergy Discontinued.

Treatment of trichomonads with the 5-LO inhibitor Docebenone, significantly inhibits the ability of trichomonads to secrete LTB4 compared to results for trichomonads treated with medium. Docebenone strongly abolishes the stimulatory effect of TvSP on IL-8 production. Docebenone at 10-200 μM increases [Ca2+]i concentration dependently.

Docebenone might protect experimental acute necrotizing pancreatitis in rats. Docebenone suppresses the release of SRS-A by 55-97%, dose-dependently in doses of 10-8-10-5 M in monkeys. The antigen-induced SRS-A release from these fragments is dose dependently inhibited by 25-93% of Docebenone, with doses of 10-8-10-5 M.

Docebenone

Immunology/Inflammation

Lipoxygenase

Lipoxygenase

Inflammation/Immunology

Allergy

80809-81-0

326.436

C21H26O3

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (765.86 mM)

O=C1C(CCCCC#CCCCC#CCO)=C(C)C(C(C)=C1C)=O

2-(12-hydroxydodeca-5,10-diynyl)- 3,5,6-trimethyl-p-benzoquinone

(-20℃)

With Ice Pack

≥ 2 years