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4E2RCat
CAS No. 432499-63-3
4E2RCat ( 4E2R Cat | 4E2R-Cat | 4E2RCat )
产品货号. M14472 CAS No. 432499-63-3
一种 eIF4E-eIF4G 相互作用的小分子抑制剂，在基于 TR-FRET 的测定中 IC50 为 13.5 uM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥2649 | 有现货 |
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| 10MG | ￥4026 | 有现货 |
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| 25MG | ￥6423 | 有现货 |
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| 50MG | ￥9153 | 有现货 |
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| 100MG | ￥12312 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称4E2RCat
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述一种 eIF4E-eIF4G 相互作用的小分子抑制剂，在基于 TR-FRET 的测定中 IC50 为 13.5 uM。
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产品描述A small molecule inhibitor of eIF4E-eIF4G interaction with IC50 of 13.5 uM in TR-FRET-based assay; inhibits cap-dependent translation in a dose-dependent manner, significantly decreases human coronavirus 229E (HCoV-229E) replication, reduces the percentage of infected cells and intra- and extracellular infectious virus titers.
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体外实验4E2RCat prevents the interaction between eIF4E (the cap-binding protein) and eIF4G (a large scaffolding protein), inhibiting cap-dependent translation. It significantly decreases human coronavirus 229E (HCoV-229E) replication, reducing the percentage of infected cells and intra- and extracellular infectious virus titers. 4E2RCat inhibits cap-dependent translation in a dose-dependent manner. 4E2RCat inhibits cap-dependent FF translation but not EMCV IRES-driven Ren translation. 4E2RCat inhibits coronavirus replication in a dose- and time-dependent manner.
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体内实验4E2RCat inhibits protein synthesis in vivo and it is not a consequence of increased cell death.
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同义词4E2R Cat | 4E2R-Cat | 4E2RCat
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通路Nuclear Receptor/Transcription Factor
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靶点eIF
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受体eIF
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研究领域Neurological Disease
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适应症——
化学信息
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CAS Number432499-63-3
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分子量455.9339
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分子式C22H14ClNO4S2
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纯度>98% (HPLC)
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溶解度DMSO: 15.5 mg/mL
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SMILESO=C(O)C1=CC(C2=CC=C(/C=C(SC(N3CC4=CC=CC=C4)=S)\C3=O)O2)=CC=C1Cl
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化学全称Benzoic acid, 2-chloro-5-[5-[[4-oxo-3-(phenylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Cencic R, et al. J Virol. 2011 Jul;85(13):6381-9.
2. Cencic R, et al. Proc Natl Acad Sci U S A. 2011 Jan 18;108(3):1046-51.
3. Bhat M, et al. Nat Rev Drug Discov. 2015 Apr;14(4):261-78.
