(Rac)-Acolbifene

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

(Rac)-Acolbifene 是 EM652（雌激素受体拮抗剂）的外消旋形式，具有抗雌激素和雌激素活性。

(Rac)-Acolbifene is the racemic form of EM652 (estrogen receptor antagonist), has anti-estrogenic and estrogenic activities.(In Vitro):In T-47D cells, (Rac)-Acolbifene (0.110 nM) inhibits cell growth with an IC50 value of 0.110 nM.(In Vivo):In ovariectomized mice, (Rac)-Acolbifene (7.5 nM, 75 nM; oral) shows shows 63% and 84% antiuterotrophic inhibitions, respectively.

(Rac)-Acolbifene (EM-343; (Rac)-EM-652)? shows a inhibitory effect in T-47D cells with an IC50 value of 0.110 nM. Cell Viability Assay Cell Line:T-47D cells Concentration:0.110 nM Incubation Time:72 hours Result:Inhibited T-47D cells growth.

(Rac)-Acolbifene (orally adminstration; 7.5 nM, 75 nM; 9 days; once daily) shows a good pharmacological profile in ovariectomized mice, shows 63% and 84% antiuterotrophic inhibitions at the 7.5 and 75 nM doses, respectively (PK study, ovariectomized mice).

EM-343 | (Rac)-EM-652

Others

Other Targets

FGFR1| FGFR2| FLT3| PDGFR| VEGFR1| VEGFR2| VEGFR3

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151533-34-5

457.57

C29H31NO4

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (218.55 mM)

CC1=C(C(Oc2cc(O)ccc12)c1ccc(OCCN2CCCCC2)cc1)c1ccc(O)cc1

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(-20℃)

With Ice Pack

≥ 2 years