(E)-Elafibranor ( R112; R112; R 112 )

产品货号. M17545 CAS No. 575474-82-7

COA

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HNMR

HPLC

MSDS

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产品名称

(E)-Elafibranor
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

R112 is an ATP-competitive inhibitor of Syk kinase.
产品描述

R112 is a Syk inhibitor. R112 inhibited degranulation induced by anti-IgE cross-linking in mast cells (tryptase release, effective concentration for 50% inhibition [EC(50)] = 353 nmol/L) or basophils (histamine release, EC(50) = 280 nmol/L), and by allergen (dust mite) in basophils (histamine release, EC(50) = 490 nmol/L). R112 also blocked leukotriene C4 production and all proinflammatory cytokines tested. Subsequent molecular characterization indicated that R112 is an ATP-competitive spleen tyrosine kinase (Syk) inhibitor (inhibitory constant [K(i)] = 96 nmol/L).
同义词

R112; R112; R 112
通路

Others
靶点

Other Targets
受体

Syk
研究领域

Inflammation/Immunology
适应症

——

1. Rossi AB, et al. J Allergy Clin Immunol. 2006 Sep;118(3):749-55.

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