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(E)-Elafibranor
CAS No. 575474-82-7
(E)-Elafibranor ( R112; R112; R 112 )
产品货号. M17545 CAS No. 575474-82-7
R112 is an ATP-competitive inhibitor of Syk kinase.
纯度: 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥381 | 有现货 |
|
| 5MG | ￥616 | 有现货 |
|
| 10MG | ￥1021 | 有现货 |
|
| 25MG | ￥1863 | 有现货 |
|
| 50MG | ￥2803 | 有现货 |
|
| 100MG | ￥4155 | 有现货 |
|
| 500MG | ￥8748 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称(E)-Elafibranor
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述R112 is an ATP-competitive inhibitor of Syk kinase.
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产品描述R112 is a Syk inhibitor. R112 inhibited degranulation induced by anti-IgE cross-linking in mast cells (tryptase release, effective concentration for 50% inhibition [EC(50)] = 353 nmol/L) or basophils (histamine release, EC(50) = 280 nmol/L), and by allergen (dust mite) in basophils (histamine release, EC(50) = 490 nmol/L). R112 also blocked leukotriene C4 production and all proinflammatory cytokines tested. Subsequent molecular characterization indicated that R112 is an ATP-competitive spleen tyrosine kinase (Syk) inhibitor (inhibitory constant [K(i)] = 96 nmol/L).
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同义词R112; R112; R 112
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通路Others
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靶点Other Targets
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受体Syk
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研究领域Inflammation/Immunology
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适应症——
化学信息
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CAS Number575474-82-7
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分子量312.3
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分子式C16H13FN4O2
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纯度98%
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溶解度DMSO : ≥ 41 mg/mL; 131.28 mM
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SMILESc1cc(cc(c1)O)Nc1nc(ncc1F)Nc1cc(ccc1)O
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化学全称3,3'-((5-fluoropyrimidine-2,4-diyl)bis(azanediyl))diphenol
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Rossi AB, et al. J Allergy Clin Immunol. 2006 Sep;118(3):749-55.
产品手册
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