Allergy is the most important immune disorder because it affects almost 30% of the population worldwide and induces inflammation in a variety of organ systems such as the upper and lower respiratory tract, the skin, the gastrointestinal tract, and the cardiovascular system.Food allergy and atopic dermatitis are less frequent than respiratory allergy but are associated with a severe reduction in the quality of life. Toll-like receptor (TLR) agonists also have been used to treat atopic conditions other than food allergy by immune deviation, and are therefore of interest as potential therapies for food allergy. CRTH2, a G protein-coupled receptor expressed by TH2 cells, eosinophils and basophils, provides another therapeutic target.Understanding the markers and mechanisms that differentiate tolerance, desensitization and sustained unresponsiveness will be useful for monitoring immunotherapy and providing the next generation of treatment targets.

References

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