Dishevelled
The well-conserved canonical and noncanonical Wnt pathways are important for all aspects of mammalian development, and various human diseases, including developmental diseases and cancer, are caused by abnormal Wnt signaling. Signals from extracellular Wnt ligands are received by three classes of coreceptors. These signals are interpreted and transduced to the nucleus and/or cytoskeleton via a number of intracellular proteins, including Dishevelleds (Dvls). In vivo pathways, Dvls regulate normal development and are disrupted in the Dvl mutants to produce these phenotypes. Identified domains in Dvl proteins required for either canonical Wnt or noncanonical Wnt/PCP pathway function. Dvl1 may play some unique role in the brain, based on the singular behavioral phenotype displayed by the Dvl1 mutants. Dvl2 and Dvl3 may have higher levels of expression in the developing heart, which could explain the conotruncal defects displayed by these mutants.
References
1.Wynshaw-Boris A,et al. Curr Top Dev Biol. 2012;101:213-35.
References
1.Wynshaw-Boris A,et al. Curr Top Dev Biol. 2012;101:213-35.
Wnt/Notch/Hedgehog
Dishevelled
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KY-02327
产品货号 : M13288
cas no: 2093407-25-9
KY-02327 是一种口服活性小分子 Disheveled (Dvl)-CXXC5 相互作用抑制剂,IC50 为 3.1 uM。 -
KY-02061
产品货号 : M13287
cas no: 2093406-88-1
KY-02061 是一种 Dishevelled-CXXC5 相互作用的小分子抑制剂,体外结合测定的 IC50 为 24 uM。 -
NSC 668036
产品货号 : M11903
cas no: 144678-63-7
NSC 668036 是 Disheveled (Dvl) PDZ 结构域的特异性抑制剂,与 GRIP 的 PSD-95、PSD95 和 PDZ7 结构域的结合极弱。