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AAK1
The adaptor-associated kinase 1 (AAK1) is originally identified as an alpha-adaptin binding protein. AAK1 is a serine/threonine kinase that is thought to coordinate the recruitment of AP-2 to receptors containing tyrosine-based internalization motifs by phosphorylating the μ2 subunit, AAK1 functions at multiple steps of the endosomal pathway by regulating transferrin internalization and its rapid recycling back to the plasma membrane from early/sorting endosome.
References:
1.Henderson DM, et al. Mol Biol Cell. 2007 Jul;18(7):2698-706.
2.Ultanir SK,et al. Neuron. 2012 Mar 22;73(6):1127-42.
References:
1.Henderson DM, et al. Mol Biol Cell. 2007 Jul;18(7):2698-706.
2.Ultanir SK,et al. Neuron. 2012 Mar 22;73(6):1127-42.
Others
AAK1
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AAK1 inhibitor 25A
产品货号 : M16970
cas no: ——
AAK1 抑制剂 25A 是 AAK1 和密切相关的激酶 BMP2K 的有效选择性抑制剂，Ki 为 8 nM (AAK1)。
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AAK1 inhibitor 1
产品货号 : M13613
cas no: 2247894-32-0
AAK1 抑制剂 1 (SGC-AAK1-1) 是一种有效的、选择性的 AAK1 和 BMP2K/BIKE 抑制剂。
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BMS-901715
产品货号 : M12595
cas no: 1699861-37-4
BMS-901715 (BMS901715) 是一种有效的、选择性的接头蛋白 2 相关激酶 1 (AAK1) 抑制剂。
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BMT-090605
产品货号 : M12203
cas no: 1551403-51-0
BMT-090605 (BMT 090605, BMT090605) 是一种有效的选择性接头蛋白 2 相关激酶 1 (AAK1) 抑制剂，IC50 为 0.6 nM。
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BMT-046091
产品货号 : M12202
cas no: 1551401-20-7
BMT-046091 (BMT046091) 是一种有效的选择性 AAK1 抑制剂，IC50 为 2.8 nM。
