MALT1
The paracaspase MALT1 has a central role in the activation of lymphocytes and other immune cells including myeloid cells, mast cells and NK cells. MALT1 activity is required not only for the immune response, but also for the development of natural Treg cells that keep the immune response in check. The paracaspase MALT1 plays an essential role in the activation of immune cells by specific subtypes of immune receptors, which induce a common signaling pathway leading to the activation of the transcription factor NF-κB. NF-κB target genes include cytokines and anti-apoptotic proteins, which together promote the activation, proliferation and survival of the activated immune cells upon receptor triggering, and thereby allow the efficient generation of an immune response. MALT1 is also involved in the activation of non-immune cells, in which an NF-κB response can be induced by specific G protein-coupled receptors (GPCRs) or the epidermal growth factor (EGF) receptor. MALT1 has an essential role in the immune response and the growth of lymphoma cells with constitutive MALT1 activity, MALT1 could be a rational drug target for immunomodulation and lymphoma treatment.
References
1.Jaworski M, et al. Cell Mol Life Sci. 2016;73(3):459–473.
References
1.Jaworski M, et al. Cell Mol Life Sci. 2016;73(3):459–473.
MALT1
-
Mepazine hydrochloride
产品货号 : M35520
cas no: 2975-36-2
Mepazine hydrochloride (Pecazine hydrochloride) 是一种有效的选择性 MALT1 蛋白酶抑制剂。Mepazine hydrochloride 抑制全长 GSTMALT1 和 GSTMALT1 325-760 段的IC50 分别为 0.83 和 0.42 μM。Mepazine hydrochloride 通过增强细胞凋亡 (apoptosis) 来影响 ABC-DLBCL 细胞的生存能力。 -
JNJ-67856633
产品货号 : M28077
cas no: 2230273-76-2
JNJ-67856633 是一种口服活性、一流的、有效的、选择性的变构 MALT1 蛋白酶抑制剂。 JNJ-67856633在某些情况下会导致肿瘤瘀滞。 -
MLT943
产品货号 : M23833
cas no: 1832576-04-1
MLT-943 是一种有效的、选择性的、具有口服活性的 MALT1 蛋白酶抑制剂。 -
MI-2
产品货号 : M10236
cas no: 1047953-91-2
MI-2(MALT1 抑制剂)是一种选择性、不可逆的 MALT1 副半胱天冬酶抑制剂,IC50 为 5.84 uM。