β2AR-IN-15 ( —— )

产品货号. M13255 CAS No. 2088234-50-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

β2AR-IN-15
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

An allosteric, small-molecule negative modulator for β2AR with Kd of 1.7 uM.
产品描述

An allosteric, small-molecule negative modulator for β2AR with Kd of 1.7 uM; binds in proximity to the G-protein binding site on the cytosolic surface of the β2AR; inhibits cAMP production through the β2AR, but not that mediated by other Gs-coupled receptors; also similarly inhibits β-arrestin recruitment to the activated β2AR.
同义词

——
通路

Angiogenesis
靶点

Adrenergic Receptor
受体

Adrenergic Receptor
研究领域

——
适应症

——

CAS Number

2088234-50-6
分子量

647.61
分子式

C34H39BrN4O4
纯度

>98% (HPLC)
溶解度

——
SMILES

——
化学全称

4-((2S)-3-(((S)-3-(3-bromophenyl)-1-(methylamino)-1-oxopropan-2-yl)amino)-2-(2-cyclohexyl-2-phenylacetamido)-3-oxopropyl)benzamide

1. Ahn S, et al. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1708-1713.

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