β2AR-IN-15
CAS No. 2088234-50-6
β2AR-IN-15 ( —— )
产品货号. M13255 CAS No. 2088234-50-6
An allosteric, small-molecule negative modulator for β2AR with Kd of 1.7 uM.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
100MG | 获取报价 | 有现货 |
|
200MG | 获取报价 | 有现货 |
|
500MG | 获取报价 | 有现货 |
|
1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称β2AR-IN-15
-
注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
-
产品简述An allosteric, small-molecule negative modulator for β2AR with Kd of 1.7 uM.
-
产品描述An allosteric, small-molecule negative modulator for β2AR with Kd of 1.7 uM; binds in proximity to the G-protein binding site on the cytosolic surface of the β2AR; inhibits cAMP production through the β2AR, but not that mediated by other Gs-coupled receptors; also similarly inhibits β-arrestin recruitment to the activated β2AR.
-
同义词——
-
通路Angiogenesis
-
靶点Adrenergic Receptor
-
受体Adrenergic Receptor
-
研究领域——
-
适应症——
化学信息
-
CAS Number2088234-50-6
-
分子量647.61
-
分子式C34H39BrN4O4
-
纯度>98% (HPLC)
-
溶解度——
-
SMILES——
-
化学全称4-((2S)-3-(((S)-3-(3-bromophenyl)-1-(methylamino)-1-oxopropan-2-yl)amino)-2-(2-cyclohexyl-2-phenylacetamido)-3-oxopropyl)benzamide
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Ahn S, et al. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1708-1713.
产品手册
关联产品
-
ICI 89406
ICI 89406 is a β-adrenergic antagonist.
-
Zinterol hydrochlori...
Zinterol (MJ 9184) is a potent and selective β2 adrenoceptor agonist with pKb of 8.3, displays >2 logs selectivity over β1 (pKb<5.7).
-
Midodrine hydrochlor...
Midodrine is a selective α1-adrenoceptor agonist that acts as a vasopressor/antihypotensive agent for the treatment of dysautonomia and orthostatic hypotension.