tcY-NH2

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Selective PAR4 antagonist peptide. Inhibits endostatin release and platelet aggregation induced by thrombin.

Selective PAR4 antagonist peptide. Inhibits endostatin release and platelet aggregation induced by thrombin.

tcY-NH2 (0-500 μM) inhibits AYPGKF-NH2 (10 μM)-induced platelet (obtained from male albino Sprague–Dawley rats) aggregation, with an IC50 value of 95 μM.tcY-NH2 potently activates aorta relaxation (RA) and gastric (LM) contraction, with IC50 values of 64 μM (RA) and 1 μM (LM).tcY-NH2 (Tc-YPGKF-NH2, 400 μM, 5 min) prevents endostatin release and platelet aggregation induced by thrombin or by AY-NH2.tcY-NH2 (5 μM, 15 min) decreases infarct size (IS) by 51%, and increases recovery of ventricular function by 26% in an isolated heart model.

tcY-NH2 (tail vein injection, 0.6 mg/kg for a single dose) alleviates liver injury in Brain death (BD) rat model, indicated by lower serum ALT/AST levels and better histomorphology.tcY-NH2 (intraperitoneal injection, 0.6 mg/kg for a single dose) increases posttraumatic activation of CD4+ Tregs within the draining lymph nodes in burn injury mice model .tcY-NH2 (intrapleural injection, 40 ng/kg for a single dose) inhibits neutrophil recruitment in experimental inflammation in mice. Animal Model:Brain death (BD) rat model Dosage:0.6 mg/kg for a single doseAdministration:Tail vein injection for a single dose Result:Reduced blood platelet activation and hepatic platelet accumulation.Attenuated the inflammatory response and apoptosis in the livers.Inhibited the activation of NF-κB and MAPK pathways induced by Brain death (BD).Animal Model:Burn injury model of C57BL/6 N mice Dosage:0.6 mg/kg for a single dose Administration:Intraperitoneal injection Result:Increased expression and phosphorylation of PKC-θ in the presence of platelets, without affecting early posttraumatic hemostasis.Animal Model:BALB/c mice Dosage:40 ng/kg for a single dose Administration:Intrapleural injection Result:Abolished the number of rolling and adhering neutrophils on the vessel wall.Inhibited CXCL8- and Cg-induced neutrophil migration into the pleural cavity of mice.

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GPCR/G Protein

PAR

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327177-34-4

739.87

C40H49N7O7

>98% (HPLC)

water:1 mg/mL

NCCCC[C@H](NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)\C=C\C1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

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(-20℃)

With Ice Pack

≥ 2 years