p-Ethynylphenylalanine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) 是一种高效、选择性的，可逆、竞争性的色氨酸羟化酶 (TPH) 抑制剂，其 Ki 值为 32.6 μM。p-Ethynylphenylalanine 是一种点击化学试剂。它含有 Alkyne 基团，可以和含有 Azide 基团的分子发生铜催化的叠氮-炔环加成反应 (CuAAc)。

p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH), with a Ki of 32.6 μM. p-Ethynylphenylalanine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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Animal Model:Male Sprague-Dawley rats (200 g) Dosage:30 mg/kg Administration:Intraperitoneal injection Result:Decreased in 5-HT and 5-HIAA levels in the rat midbrain.

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Immunology/Inflammation

Hydroxylase

Hydroxylase

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278605-15-5

189.21

C11H11NO2

>98% (HPLC)

In Vitro:?1M HCl 中的溶解度 : 240 mg/mL (1268.43 mM; 超声助溶 酸性条件溶解 (HCL 调节，pH≈1))1M NaOH 中的溶解度 : 240 mg/mL (1268.43 mM; ultrasonic and adjust pH to 11 with NaOH) DMSO 中的溶解度 : 2.22 mg/mL (11.73 mM; 超声助溶 )

N[C@@H](Cc1ccc(cc1)C#C)C(O)=O

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(-20℃)

With Ice Pack

≥ 2 years