kaempferide

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Kaempferide trigluside 通过一种不由配体结合依赖性雌激素受体激活介导的机制抑制天然和雌激素受体β过度表达的结肠癌细胞的增殖。

Kaempferide triglycoside inhibits the proliferation of native and estrogen receptor beta overexpressing colon cancer cells through a mechanism not mediated by ligand binding dependent estrogen receptor activation.

Western Blot Analysis Cell Line:HepG2Concentration:5 μM, 10 μM, 20 μM . Before treatment with OA (HY-N1446) (0.5 mM; 48 h)Incubation Time:48 h Result:Lowered the expression of proteins related to fat production, including sterol regulatory element-binding protein 1 (SREBP1), fatty acid synthase (FAS), and stearoyl-CoA desaturase 1 (SCD-1).Reduced the expression of two adipogenic transcription factors, peroxisome proliferator-activated receptor gamma (PPARγ) and CCAAT enhancer-binding protein β (C/EBPβ).Enhanced the expression of heme oxygenase-1 (HO-1) and nuclear factor erythroid 2-related factor 2 (Nrf2).

Animal Model:High-fat diet male C57BL/6J mice modelDosage:10 mg/kg Administration:Supplemented in daily diet, once daily for16 weeksResult:Reduced the weight, organ weight, and index of mice.Lowered the levels of glycolipids in mouse serum.Decreased the expression levels of inflammatory-related genes, including NF-κB, IL-6, ICAM-1, VCAM-1, and TNF-α.Animal Model:Ischemia/Reperfusion (I/R) SD rat model.Dosage:0.1 mg/kg, 0.3 mg/kg, 3 mg/kg Administration:Injection, Single dose. Before the I/R injury induced by Coronary Artery Ligation (CAL) in SD rats.Result:Significantly improved heart function, reduced myocardial injury by reducing myocardial enzyme levels, and dose-dependently reduced the area of myocardial infarction in rats.Significantly decreased serum levels of TNF-α, IL-6, C-reactive protein (CRP), MDA, and ROS, while increasing serum levels of SOD.Downregulated the expression levels of nuclear factor erythroid 2-related factor 2 (Nrf2) and cleaved caspase-3, and upregulated the phosphorylation expression levels of phospho-Akt (p-Akt) and phospho-glycogen synthase kinase-3β (p-GSK-3β).

Kaempferide

Others

Other Targets

ER

Others-Field

——

491-54-3

300.27

C16H12O6

>98% (HPLC)

DMSO : 20 mg/mL 66.61 mM;

COc1ccc(cc1)c1c(c(=O)c2c(cc(cc2o1)O)O)O

3,5,7-trihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one

(-20℃)

With Ice Pack

≥ 2 years