iGOT1-01
CAS No. 882256-55-5
iGOT1-01 ( —— )
产品货号. M28579 CAS No. 882256-55-5
iGOT1-01 is an effective inhibitor of glutamate oxaloacetate transaminase 1(GOT1) . iGOT1-01 has IC50s of 84.6 μM and 11.3 μM in GOT1/MDH1 assay and GOT1/GLOX/HRP assay, respectively. iGOT1-01 can be used in anti-cancer studies.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥2341 | 有现货 |
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10MG | ¥3750 | 有现货 |
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25MG | ¥6059 | 有现货 |
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50MG | ¥7995 | 有现货 |
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100MG | ¥11178 | 有现货 |
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500MG | ¥22437 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称iGOT1-01
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述iGOT1-01 is an effective inhibitor of glutamate oxaloacetate transaminase 1(GOT1) . iGOT1-01 has IC50s of 84.6 μM and 11.3 μM in GOT1/MDH1 assay and GOT1/GLOX/HRP assay, respectively. iGOT1-01 can be used in anti-cancer studies.
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产品描述iGOT1-01 is an effective inhibitor of glutamate oxaloacetate transaminase 1(GOT1) . iGOT1-01 has IC50s of 84.6 μM and 11.3 μM in GOT1/MDH1 assay and GOT1/GLOX/HRP assay, respectively. iGOT1-01 can be used in anti-cancer studies.(In Vitro):iGOT1-01 (3.125-200 μM; for 3 h) reveals little to no toxicity using two readouts of cell viability in PaTu8902 pancreatic and DLD1 colon cancer cells. No inhibitory activity is observed for iGOT1-01 against MDH1 alone at 100 μM.(In Vivo):In female CD1 mice, iGOT1-01 (20 mg/kg; oral) has reasonable bioavailability and exposure properties (t1/2=0.7 hours, Cmax=4133 ng/mL, AUC(0-24 hours)=11734 hour ng/mL).
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同义词——
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通路Others
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靶点Other Targets
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number882256-55-5
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分子量320.4
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分子式C19H20N4O
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纯度>98% (HPLC)
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溶解度——
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SMILESO=C(N1CCN(C2=CC=CC3=C2C=CN3)CC1)NC4=CC=CC=C4
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Ozeki K, et al. Studies on antiallergy agents. III. Synthesis of 2-anilino-1,6-dihydro-6-oxo-5-pyrimidinecarboxylic acids and related compounds. Chem Pharm Bull (Tokyo). 1989 Jul;37(7):1780-7.
产品手册
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