gamma-Tocotrienol ( Plastochromanol | D-gamma-Tocotrienol | gamma-Tocotrienol | gamma Tocotrienol | gammaTocotrienol )

产品货号. M23566 CAS No. 14101-61-2

γ-生育三烯酚是四种生育三烯酚之一，是维生素 E 的一种。Itl 也是一种辐射防护剂、抗氧化剂。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
2MG	￥454	有现货
5MG	￥753	有现货
10MG	￥1191	有现货
25MG	￥2009	有现货
50MG	￥2989	有现货
100MG	￥4398	有现货
200MG	获取报价	有现货
500MG	获取报价	有现货
1G	获取报价	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

gamma-Tocotrienol
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

γ-生育三烯酚是四种生育三烯酚之一，是维生素 E 的一种。Itl 也是一种辐射防护剂、抗氧化剂。
产品描述

gamma-Tocotrienol is one of the four types of tocotrienol, a type of vitamin E. Itl is also a radioprotector, antioxidant. It shows antitumor and antihypertensive effects in vivo.
体外实验

γ-Tocotrienol (25 μM; 24 h) effectively inhibits the expression levels of mdr1 mRNA and P-gp protein, (25 μM and 50 μM; 24 h) suppresses mdr1 promoter activity and the efflux activity of P-gp as well.γ-Tocotrienol (25 μM and 50 μM; 24 h) reduces the activation of NF-κB signaling pathway and the transcriptional activity of NF-κB.γ-tocotrienol (50 μM; 48 h) effectively inhibits the process of nuclear translocation of p65 which was induced by TNFα. Immunofluorescence Cell Line:MCF-7/Adr cells Concentration:50 μM Incubation Time:48 hours Result:Decreased the red fluorescence of p65 in the nucleus, indicating nuclear translocation inhibiton of p65 induced by TNFα.
体内实验

γ-Tocotrienol’s liposomal formulation, GT3-Nano (20 mol% γ-Tocotrienol), (10 mg/kg, 6 mol%; i.v.; single dose, observed for 100 d) is highly effective in mitigating the marrow-suppressive effects of sublethal and lethal TBI in mice. GT3-Nano (50 mg/kg; i.v.; ) can facilitate rapid recovery of hematopoietic components in mice treated with the endoradiotherapeutic agent 153Sm-EDTMP. Animal Model:C57/BL6 mice (6-8 weeks old) treated with the whole-body irradiation Dosage:16, 24, 32, and 50 mg/kg Administration:Intravenous injection; observed mice for 100 days Result:Demonstrated dose-dependent radioprotection, achieving 90% survival at 50 mg/kg against lethal 9-Gy of total-body irradiation (TBI).And upregulated progenitor bone marrow cells MPP2 and CMP in GT3-Nano-treated mice.
同义词

Plastochromanol | D-gamma-Tocotrienol | gamma-Tocotrienol | gamma Tocotrienol | gammaTocotrienol
通路

Others
靶点

Other Targets
受体

Others
研究领域

——
适应症

——

化学信息

CAS Number

14101-61-2
分子量

410.64
分子式

C28H42O2
纯度

>98% (HPLC)
溶解度

DMSO:100 mg/mL (243.53 mM; Need ultrasonic)
SMILES

OC1=C(C)C(C)=C2C(CC[C@](CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/C)(C)O2)=C1
化学全称

——

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1.Hofer M, Hoferová Z, Falk M. Pharmacological Modulation of Radiation Damage. Does It Exist a Chance for Other Substances than Hematopoietic Growth Factors and Cytokines? Int J Mol Sci. 2017 Jun 28;18(7). pii: E1385. doi: 10.3390/ijms18071385. Review. PubMed PMID: 28657605; PubMed Central PMCID: PMC5535878.

计算器

浓度计算器

摩尔计算器

分子量计算器

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