cjoc42

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

cjoc42 是 gankyrin 的抑制剂，gankyrin 是一种锚蛋白重复癌蛋白，其过度表达与许多癌症类型的发展有关。

cjoc42 is an inhibitor of gankyrin, an ankyrin-repeat oncoprotein whose overexpression has been implicated in the development of many cancer types. cjoc42 prevents the decrease in p53 protein levels normally associated with high amounts of gankyrin, and it restores p53-dependent transcription and sensitivity to DNA damage(In Vitro):cjoc42 (0.1, 1, and 10 μM) alone showed no dose-dependent change in cell viability. cjoc42 (0.5, 1, and 5 μM) inhibited gankyrin-induced lowering of p53 levels in cells.

cjoc42 (0.5, 1, and 5 μM; 48 hours) dose-dependently restores p53 levels (comparable to mock transfected cells) and inhibits gankyrin-induced lowering of p53 levels in cells.cjoc42 (0.1, 1, and 10 μM; 24 hours) alone shows no dose-dependent change in cell viability. Western Blot Analysis Cell Line:U2OS Concentration:0.5, 1, and 5 μMIncubation Time:48 hours Result:Dose-dependent restoration of p53 levels (comparable to mock transfected cells) and inhibited gankyrin-induced lowering of p53 levels in cells.

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cjoc-42 | cjoc 42

Others

Other Targets

NOS

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2171519-89-2

415.46

C20H21N3O5S

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (240.70 mM)

O=C(OC)C1=CC=C(N2N=NC(CCCOS(=O)(C3=CC=C(C)C=C3)=O)=C2)C=C1

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(-20℃)

With Ice Pack

≥ 2 years