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alpha-Asarone

CAS No. 2883-98-9

alpha-Asarone ( α-Asarone | trans-Asarone )

产品货号. M18369 CAS No. 2883-98-9

α-细辛脑是一种精神活性化合物,对小鼠具有抗抑郁样活性。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
10MG ¥441 有现货
25MG ¥688 有现货
50MG ¥988 有现货
100MG 获取报价 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    alpha-Asarone
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    α-细辛脑是一种精神活性化合物,对小鼠具有抗抑郁样活性。
  • 产品描述
    Alpha-Asarone is a psychoactive compound with antidepressant-like activity in mice.(In Vitro):The results indicated that α-asarone significantly attenuated the LPS-stimulated increase in neuroinflammatory responses and suppressed pro-inflammatory cytokine production in BV-2 cells. Mechanistic study revealed that alpha-Asarone (α-Asarone) inhibited the LPS-stimulated activation via regulation of nuclear factor kappa-B by blocking degradation of inhibitor kappa B-alpha signaling in BV-2 microglial cells.(In Vivo):The present results reveal that the acute treatment of alpha-Asarone (α-Asarone) elicited biphasic responses on immobility such that the duration of the immobility time is significantly reduced at lower doses (15 and 20 mg/kg, i.p.) but increased at higher doses (50 and 100 mg/kg, i.p.) in the TST. Besides, alpha-Asarone (α-Asarone) at higher doses (50 and 100 mg/kg, i.p.) significantly decreased the spontaneous locomotor activity.
  • 体外实验
    The results indicated that α-asarone significantly attenuated the LPS-stimulated increase in neuroinflammatory responses and suppressed pro-inflammatory cytokine production in BV-2 cells. Mechanistic study revealed that alpha-Asarone (α-Asarone) inhibited the LPS-stimulated activation via regulation of nuclear factor kappa-B by blocking degradation of inhibitor kappa B-alpha signaling in BV-2 microglial cells.
  • 体内实验
    The present results reveal that the acute treatment of alpha-Asarone (α-Asarone) elicited biphasic responses on immobility such that the duration of the immobility time is significantly reduced at lower doses (15 and 20 mg/kg, i.p.) but increased at higher doses (50 and 100 mg/kg, i.p.) in the TST. Besides, alpha-Asarone (α-Asarone) at higher doses (50 and 100 mg/kg, i.p.) significantly decreased the spontaneous locomotor activity.
  • 同义词
    α-Asarone | trans-Asarone
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    HMGCR| CYP2D6| CYP3A4
  • 研究领域
    Neurological Disease
  • 适应症
    ——

化学信息

  • CAS Number
    2883-98-9
  • 分子量
    208.3
  • 分子式
    C12H16O3
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO : 100 mg/mL 480.19 mM; H2O : < 0.1 mg/mL
  • SMILES
    C/C=C/c1cc(c(cc1OC)OC)OC
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Limón, L, et al. Neuroscience Letters 453(2), 2009, 98-103.
产品手册
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