Zotarolimus

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Zotarolimus (ABT-578, A 179578) 是雷帕霉素的半合成类似物，抑制 FKBP-12。

Zotarolimus (ABT-578, A 179578) is a semi-synthetic analogue of rapamycin, inhibits FKBP-12 binding with IC50 of 2.8 nM and shows less potent systemic immunosuppression than rapamycin; effectively inhibits both smooth muscle cell and endothelial cell proliferation, with IC50 values of 2.9 nM and 2.6 nM, respectively; exhibits high-affinity binding to the immunophilin FKBP12, inhibiting in vitro proliferation of both human and rat T cells; inhibits Con A-induced human T cells with IC50 of 7.0 nM; reduce early complications and improve late clinical outcomes in patients needing interventional cardiology.

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ABT-578 | A-179578 | ABT578 | A179578 | ABT 578 | A 179578

PI3K/Akt/mTOR signaling

mTOR

FKBP-12

Cancer

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221877-54-9

966.21

C52H79N5O12

>98% (HPLC)

DMSO: ≥ 33 mg/mL

O=C([C@@](CCCC1)([H])N1C(C([C@@]2(O)[C@H](C)CC[C@@](O2)([H])C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C([C@H](OC)[C@H](O)/C(C)=C/[C@H]3C)=O)=O)=O)O[C@H]([C@H](C)C[C@H]4C[C@@H](OC)[C@@H](N5N=NN=C5)CC4)CC3=O

Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-

(-20℃)

With Ice Pack

≥ 2 years