Zinterol

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Zinterol (MJ 9184) 是一种有效的选择性 β2 肾上腺素受体激动剂，pKb 为 8.3，显示出比 β1 >2 个对数的选择性 (pKb<5.7)。

Zinterol (MJ 9184) is a potent and selective β2 adrenoceptor agonist with pKb of 8.3, displays >2 logs selectivity over β1 (pKb<5.7); reduces response rate and increases reinforcement rate of rats under a differential-reinforcement-of-low-rate schedule in a dose-dependent manner; significant decreases in response rate and increases in reinforcement rate were observed at doses of 0.1-1 mg/kg.

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Zinterol (2.5 μg/kg i.v. bolus over 5 s) leads to ventricular arrhythmias including premature ventricular complexes (PVCs) and runs of ventricular tachycardia (VT) in heart failure (HF) rabbits. Zinterol at a lower dose (1 μg/kg i.v, n=4) does not induce ventricular arrhythmias in HF rabbits. Animal Model:In New Zealand White HF rabbits of either sex Dosage:1.0 or 2.5 μg/kg Administration:Intravenous bolus administration; over 5 seconds Result:2.5 μg/kg did not significantly alter heart rate or mean arterial blood pressure in either control or HF rabbits. 2.5 μg/kg led to ventricular arrhythmias including PVCs and runs of VT (up to 13 beats long) in 4 of 6 HF rabbits (vs 0 of 5 controls, p<0.01). 1 μg/kg did not induce ventricular arrhythmias in HF rabbits.

MJ 9184

Angiogenesis

Adrenergic Receptor

Adrenergic Receptor

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37000-20-7

378.487

C19H26N2O4S

>98% (HPLC)

In Vitro:?DMSO : 38 mg/mL (100.40 mM)

CC(C)(CC1=CC=CC=C1)NCC(C2=CC(=C(C=C2)O)NS(=O)(=O)C)O

N-[5-[2-[(1,1-Dimethyl-2-phenylethyl)amino]-1-hydroxyethyl]-2-hydroxyphenyl]methanesulphonamide

(-20℃)

With Ice Pack

≥ 2 years