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Zaprinast
CAS No. 37762-06-4
Zaprinast ( M&B 22948 )
产品货号. M14302 CAS No. 37762-06-4
Zaprinast (M&B 22948) is a potent, cGMP-specific phosphodiesterase inhibitor with IC50 of 0.5-0.76 and 0.15 uM for PDE5 and PDE6 respectively.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 10MG | ￥446 | 有现货 |
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| 25MG | ￥786 | 有现货 |
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| 50MG | ￥1393 | 有现货 |
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| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Zaprinast
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Zaprinast (M&B 22948) is a potent, cGMP-specific phosphodiesterase inhibitor with IC50 of 0.5-0.76 and 0.15 uM for PDE5 and PDE6 respectively.
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产品描述Zaprinast (M&B 22948) is a potent, cGMP-specific phosphodiesterase inhibitor with IC50 of 0.5-0.76 and 0.15 uM for PDE5 and PDE6 respectively, also is an agonist for GPR35 (EC50=16/840 nM for rat/human GPR35); weakly inhibits PDE9, PDE10, and PDE11 with IC50 of 10-30 uM; enhances the vasodilatory effects of nitric oxide in a range of vascular tissues by prolonging the cGMP-mediated activation of cGMP-dependent protein kinase; also reduces cellular 2HG levels by inhibiting the upstream enzyme glutaminase (GLS), reverses histone hypermethylation and soft-agar growth of IDH1-mutant cells.Asthma Discontinued
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同义词M&B 22948
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通路Angiogenesis
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靶点PDE
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受体PDE
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研究领域Inflammation/Immunology
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适应症Asthma
化学信息
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CAS Number37762-06-4
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分子量271.30
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分子式C13H13N5O2
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纯度>98% (HPLC)
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溶解度——
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SMILESO=C1C(NN=N2)=C2NC(C3=CC=CC=C3OCCC)=N1
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化学全称3,6-dihydro-5-(2-propoxyphenyl)-7H-1,2,3-triazolo[4,5-d]pyrimidin-7-one
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Elhammali A, et al. Cancer Discov. 2014 Jul;4(7):828-39.
2. Taniguchi Y, et al. FEBS Lett. 2006 Sep 18;580(21):5003-8.
3. Frossard N, et al. Br J Pharmacol. 1981 Aug;73(4):933-8.
4. Griffith TM, et al. Eur J Pharmacol. 1985 Jun 7;112(2):195-202.
2. Taniguchi Y, et al. FEBS Lett. 2006 Sep 18;580(21):5003-8.
3. Frossard N, et al. Br J Pharmacol. 1981 Aug;73(4):933-8.
4. Griffith TM, et al. Eur J Pharmacol. 1985 Jun 7;112(2):195-202.
产品手册
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