021-51111890
购物车（）
sales@molnova.cn
ZLD1039
CAS No. 1826865-46-6
ZLD1039 ( —— )
产品货号. M34479 CAS No. 1826865-46-6
ZLD1039 是一种口服有效的、高选择性 EZH2 抑制剂。ZLD1039 高效抑制 EZH2 野生型及 Y641F 和 A677G 突变型，IC50 分别为 5.6、15 和 4.0?nM。ZLD1039 抑制乳腺肿瘤的生长和转移。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥388 | 有现货 |
|
| 5MG | ￥541 | 有现货 |
|
| 10MG | ￥856 | 有现货 |
|
| 25MG | ￥1861 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称ZLD1039
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述ZLD1039 是一种口服有效的、高选择性 EZH2 抑制剂。ZLD1039 高效抑制 EZH2 野生型及 Y641F 和 A677G 突变型，IC50 分别为 5.6、15 和 4.0?nM。ZLD1039 抑制乳腺肿瘤的生长和转移。
-
产品描述ZLD1039 is a potent, highly selective, and orally bioavailable EZH2 inhibitor. ZLD1039 shows potent and concentration-dependent inhibition of PRC2 enzymatic activity against EZH2 wild-type as well as Y641F, and A677G mutant enzymes with IC50 values of 5.6, 15, and 4.0?nM, respectively. ZLD1039 inhibits breast tumor growth and metastasis.
-
体外实验——
-
体内实验——
-
同义词——
-
通路Others
-
靶点Other Targets
-
受体Histone Methyltransferase
-
研究领域——
-
适应症——
化学信息
-
CAS Number1826865-46-6
-
分子量612.8
-
分子式C36H48N6O3
-
纯度>98% (HPLC)
-
溶解度In Vitro:?DMSO 中的溶解度 : 9.09 mg/mL (14.83 mM; ultrasonic and adjust pH to 3 with 1M HCl )
-
SMILESCCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c3CCCCc3c(C)[nH]c2=O)c1C)-c1ccc(nc1)N1CCN(C)CC1
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Xuejiao Song, et al. Selective inhibition of EZH2 by ZLD1039 blocks H3K27methylation and leads to potent anti-tumor activity in breast cancer. Sci Rep. 2016; 6: 20864.
产品手册
关联产品
-
4-(1,3-Dihydroxy-2-p...
Glycerol-2-(3-methoxy-4-hydroxybenzoicacid)ether is a phenolic derivative and can be isolated from Picrasma quassioides (D. Don) Benn.
-
3-Phenyl-2-propen-1-...
The compounds 3-phenyl-2-propen-1-ol , 2-methyl-3-butyn-2-ol, 3,7-dimethylnonane, and 2-hydroxybenzoic acid occurred only during estrus which may be considered as marker for detection of estrus which would ultimately help for artificial insemination in captive condition.
-
Abagovomab
Abagovomab (Anti-Human CA-125 Recombinant Antibody) 是一种小鼠单克隆抗独特型抗体，靶向肿瘤相关抗原 CA-125。Abagovomab 由小鼠杂交瘤细胞产生，可以模仿人的 TAA, CA-125。Abagovomab 还能够诱导卵巢癌 (oc) 的体液和细胞免疫反应。
