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ZGN-1061
CAS No. 2082752-83-6
ZGN-1061 ( Aclimostat | ZGN1061 )
产品货号. M13245 CAS No. 2082752-83-6
ZGN-1061 (Aclimostat) 是一种新型有效的选择性蛋氨酸氨基肽酶 2 (MetAP2) 抑制剂，正在研究用于治疗糖尿病和肥胖症。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥7622 | 有现货 |
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| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称ZGN-1061
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述ZGN-1061 (Aclimostat) 是一种新型有效的选择性蛋氨酸氨基肽酶 2 (MetAP2) 抑制剂，正在研究用于治疗糖尿病和肥胖症。
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产品描述ZGN-1061 (Aclimostat) is a novel potent, selective Methionine aminopeptidase 2 (MetAP2) inhibitor being investigated for treatment of diabetes and obesity; reduces body weight in diet-induced obese (DIO) insulin-resistant mice, also produced improvements in metabolic parameters, including plasma glucose and insulin, and, in HepG2 cells, initiated gene changes similar to beloranib; does not increase coagulation markers in dogs and ZGN-1061 had a greatly improved safety profile in rats relative to beloranib.Diabetes Phase 2 Clinical.
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体外实验——
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体内实验——
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同义词Aclimostat | ZGN1061
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通路Metabolic Enzyme/Protease
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靶点Aminopeptidase
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受体Aminopeptidase
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研究领域Metabolic Disease
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适应症Diabetes
化学信息
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CAS Number2082752-83-6
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分子量478.63
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分子式C26H42N2O6
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 230 mg/mL (480.55 mM)
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SMILESO=C(N1CC(CCN2CCOCC2)C1)O[C@H](CC3)[C@@H](OC)[C@H]([C@@]4(C)O[C@@H]4C/C=C(C)\C)[C@]53CO5
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化学全称(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3- methylbut-2-en-1-yl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl 3-[2-(morpholin-4-yl)ethyl]azetidine-1-carboxylate
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Burkey BF, et al. J Pharmacol Exp Ther. 2018 Feb 28. pii: jpet.117.246272.
