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ZD-0892
CAS No. 171964-73-1
ZD-0892 ( —— )
产品货号. M33177 CAS No. 171964-73-1
ZD-0892是选择性和有效的中性粒细胞弹性蛋白酶 (neutrophil elastase) 抑制剂，对于人嗜中性粒细胞弹性蛋白酶和猪胰弹性蛋白酶的 Ki 值分别为6.7和200 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥1537 | 有现货 |
|
| 5MG | ￥2366 | 有现货 |
|
| 10MG | ￥3900 | 有现货 |
|
| 25MG | ￥7007 | 有现货 |
|
| 50MG | ￥9619 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称ZD-0892
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述ZD-0892是选择性和有效的中性粒细胞弹性蛋白酶 (neutrophil elastase) 抑制剂，对于人嗜中性粒细胞弹性蛋白酶和猪胰弹性蛋白酶的 Ki 值分别为6.7和200 nM。
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产品描述ZD-0892 is a selective and potent inhibitor of a neutrophil elastase with Kis of 6.7 and 200 nM for human neutrophil elastase and porcine pancreatic elastase, respectively.
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体外实验——
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体内实验ZD0892 administration to DBA/2 mice infected with the EMC virus results in reduced myocardial elastolytic activity and coronary microvascular perfusion injury. ZD0892 decreases the pathologic severity of the myocardial lesions associated with murine viral myocarditis. ZD-0892 can reverse advanced pulmonary vascular disease produced in rats.
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同义词——
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通路Proteasome/Ubiquitin
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靶点Serine Protease
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受体Serine Protease
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研究领域——
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适应症——
化学信息
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CAS Number171964-73-1
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分子量499.52
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分子式C24H32F3N3O5
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 250 mg/mL (500.48 mM; 超声助溶 )
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SMILESCOc1ccc(cc1)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)F
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Lee JK, et al. A serine elastase inhibitor reduces inflammation and fibrosis and preserves cardiac function after experimentally-induced murine myocarditis. Nat Med. 1998 Dec;4(12):1383-91.?
产品手册
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