Z-JIB-04

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

JIB-04 Z-异构体，也称为 NSC 693627，是 JIB-04 的异构体。 JIB-04 是一种 Jumonji 组蛋白去甲基酶抑制剂。

JIB-04 Z-isomer, also known as NSC 693627, is an isomer of JIB-04. JIB-04 is a Jumonji histone demethylase inhibitor. JIB-04 selectively blocks cancer cell growth in vitro and diminishes tumor growth in H358 and A549 mouse xenograft models in vivo. JIB-04 can prolong survival in a mouse model of breast cancer.

JIB-04 inhibits the demethylase activity of Jumonji enzymes in vitro and in cells, without affecting other α-ketoglutarate dependent hydroxylases or histone modifying enzymes .

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NSC 693627

Others

Other Targets

Others

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199596-24-2

308.76

C17H13ClN4

>98% (HPLC)

DMSO: 10 mM

ClC1=CN=C(N/N=C(C2=CC=CC=C2)\C3=NC=CC=C3)C=C1

(Z)-5-chloro-2-(2-(phenyl(pyridin-2-yl)methylene)hydrazinyl)pyridine

(-20℃)

With Ice Pack

≥ 2 years