YM17E ( —— )

产品货号. M26512 CAS No. 124900-72-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

YM17E
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

YM17E is an inhibitor of ACAT with IC50 of 44 nM in rabbit liver microsomes in vitro.
产品描述

YM17E is an inhibitor of ACAT with IC50 of 44 nM in rabbit liver microsomes in vitro.(In Vitro):YM17E is potent in inhibiting ACAT activity in the intestine with IC50 of 34 nM.(In Vivo):YM17E inhibits the production of [14C]cholesteryloleate from [14C]oleoyl CoA in a dose-dependent manner in both liver and intestinal microsomes used as enzyme sources. YM17E (3, 5, 10 mg/kg, i.v.) significantly inhibits hepatic ACAT activities in a dose-dependent manner. YM17E (oral; i.v.) produces a significant increase in 125I-LDL clearance in atherogenic diet-fed rats. YM17E (3, 10, 30 mg/kg; p.o.) decreases total cholesterol, cholesteryl ester, and non-HDL cholesterol in a dose-dependent manner. YM17E (oral) decreases total cholesterol and cholesteryl ester levels in the liver significantly in a dose-dependent manner.
同义词

——
通路

Others
靶点

Other Targets
受体

HCV
研究领域

——
适应症

——

CAS Number

124900-72-7
分子量

652.9
分子式

C40H56N6O2
纯度

>98% (HPLC)
溶解度

——
SMILES

CN(C)c1ccc(NC(=O)N(Cc2cccc(CN(C3CCCCCC3)C(=O)Nc3ccc(cc3)N(C)C)c2)C2CCCCCC2)cc1
化学全称

——

1.Makonen Belema, et al. Hepatitis C virus inhibitors. US8329159B2.

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